2020 Fiscal Year Annual Research Report
Three-Dimensional Biodegradable Nanofibers for Multifunctional Cardiac Patch
| Project/Area Number |
19F19362
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| Research Institution | The University of Tokyo |
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Principal Investigator |
染谷 隆夫 東京大学, 大学院工学系研究科(工学部), 教授 (90292755)
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| Co-Investigator(Kenkyū-buntansha) |
WANG CHUNYA 東京大学, 工学(系)研究科(研究院), 外国人特別研究員
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| Project Period (FY) |
2019-11-08 – 2022-03-31
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| Keywords | Nanomesh bioelectrodes / Silk / Electrospinning / Gold deposition |
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| Outline of Annual Research Achievements |
Biocompatible and biodegradable conductive biogels were designed and prepared with on-skin paintable capability for high-fidelity electrophysiological recordings made from cost-effective, naturally-derived and food-exploitable constituents, and were easily synthesizable. As-designed biogels showed temperature-controlled reversible phase transition between viscous liquid and viscoelastic gel, which endowed them with on-skin painted capability, good biomechanical interaction with skin, as well as the ability as improved interfaces for both non-hairy and hairy skin for high-fidelity and long-term stable electrophysiological recording. Such on-skin paintable biogel offers a biocompatible, reliable, highly effective and stable interface for high-performance epidermal recording bioelectronics.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The concept about developing on-skin paintable biogel was first tried and demonstrated feasible, so the research went ahead as planned.
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| Strategy for Future Research Activity |
To make the as-designed biogel suitable for on-skin usability, the phase transition temperature point of the biogel would be optimized by adjusting the crosslink density of biogel matrix. The physical, mechanical and electrical properties of the optimized biogel would be characterized to show its superior features compared to commercial conductive gels or pastes. ECG/EMG recording, and EEG recording through scalp with dense hairs would be conducted by applying such as-designed biogel as interface. The motion artifacts and long-term stability of electrophysiological recording based on such biogel would also be conducted to show its superiority.
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