2020 Fiscal Year Annual Research Report
A Novel fabrication of dissoluble microneedle Patch for bio-medical applications and monitoring
| Project/Area Number |
19F19725
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
金 範ジュン 東京大学, 生産技術研究所, 教授 (60334356)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
BONFANTE GWENAEL 東京大学, 生産技術研究所, 外国人特別研究員
|
|---|
| Project Period (FY) |
2019-04-25 – 2021-03-31
|
| Keywords | マイクロニードル / バイオセンサー / グルコースセンサー / 生体分解性ポリマー / 低侵襲血糖値センサー / DDS |
|---|
| Outline of Annual Research Achievements |
本研究の目的は、生体分解性かつ多孔質のマイクロニードルを製作し、DDS応用ではなく、生体内の物質（例え、細胞間体質）を吸収できるニードルアレーを製作することで、様々な生体分解性ポリマーを用いた多孔質マイクロニードルの製作方法を最適化、確立し、大量生産が可能な最適化製造基盤を目指した。
Monitoring chemical and biological compositions of bio-fluids in human body is a key parameter of for diagnosing diseases nowadays. For continuous monitoring, a promising candidate is the porous microneedles. Porous microneedles made of biodegradable and bio-compatible materials, processed to make them porous are attractive alternative for continuous sensing and diagnosis of bio-fluids.
In this research, glucose sensing through the microneedles were achieved using the experimental array presented previously. Indeed, a better understanding of the mechanism involved in the fluid collection was achieved as well as an optimization of the process: temperature of treatment, ratio porogen/material. Full characterization of the device including mechanical strength, fluid intake, SEM observation has been done.
|
| Research Progress Status |
令和2年度が最終年度であるため、記入しない。
|
| Strategy for Future Research Activity |
令和2年度が最終年度であるため、記入しない。
|
Research Products
(12 results)
