酸素や食物が内包する毒性に対する細胞の適応・応答の分子機構の解明

2009 Fiscal Year Annual Research Report

• Project/Area Number: 19GS0312
• Research Institution: Tohoku University
• Principal Investigator: 山本 雅之 Tohoku University, 大学院・医学系研究科, 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): 勝岡 史城 東北大学, 大学院・医学系研究科, 准教授 (30447255)
• Keywords: Nrf2 / Keap1 / 酸化ストレス / 低酸素 / エリスロポエチン

Research Abstract

生体は、環境ストレスに適切に応答して恒常性を維持している。本研究は、生体がストレスを感知するセンサーの分子機構と、ストレスによって惹起される生体防御機構の解明を目的としている。
Nrf2-Keap1システムによるストレス感知機構および同システムと発癌との関連性の解析:電子線単粒子解析により、酸化ストレスセンサーであるKeap1分子の全長構造を明らかにした。疾患との関連については、マウスの喫煙モデルにおいて、Nrf2が肺気腫に対して保護的な役割を果たしていることを実証した。また、Keap1欠損マウスを用いた解析で、親電子性物質刺激によるNrf2標的遺伝子の誘導と遺伝子の発現誘導の比較検討を実施し、新たなNrf2活性化機構が存在することを明らかにした。本研究成果は、Nrf2活性化は単にNrf2蛋白質の蓄積だけでなく他のシグナル経路が深く関与している可能性を示唆している。疾患予防を目指したNrf2活性剤開発においても重要知見である。
エリスロポエチン(Epo)遺伝子制御機構と低酸素感知機構の解析:Epo遺伝子領域を含む大腸菌人工染色体の導入によるEpo遺伝子欠損マウスのレスキュー実験を行った。レスキューマウスではEpo欠損による胎生致死性は回避され、成体に貧血や多血症は認められず、貧血誘導に対するEpo産生、および、赤血球産生の反応も野生型と同等であった。同じ領域を用いた緑色蛍光蛋白質(GFP)レポーターマウスにおいて腎臓Epo発現細胞におけるGFP発現を認められ、この領域内に内在性Epo発現を過不足なく再現可能な転写活性が存在することが示された。一方、トランスジェニックレポーター法による検討を重ね、Epo遺伝子上流の領域に腎臓における低酸素誘導性の発現を制御する領域があることを明らかにした。また、GFP発現を指標に腎臓におけるEpo産生細胞を単離し、遺伝子発現解析を行った。

Research Products

• [Journal Article] NF-E2-related factor 2 regulates the stress response to UVA-1-oxidized phospholipids in skin cells (2010)
  • Author(s): Gruber F, Mayer H, Lengauer B, Mlitz V, Sanders JM, Kadl A, Bilban M, de Martin R, Wagner O, Kensler TW, Yamamoto M, Leitinger N, Tschachler E.
  • Journal Title: FASEB J 24 Pages: 39-48
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• [Journal Article] Role of NrfZ and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells (2010)
  • Author(s): Kosaka K, Mimura J, Itoh K, Satoh T, Shimojo Y, Kitajima C, Maruyama A, Yamamoto M, Shirasawa T.
  • Journal Title: J.Biochem. 147 Pages: 73-81
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• [Journal Article] Irreversible down-regulation of UDP-glucuronosyltransferases through AhR inactivation during urinary bladder carcinogenesis (2010)
  • Author(s): Iida K, Itoh K, Mimura J, Ohyama C, Fujii-Kuriyama Y, Shimazui T, Akaza H, Yamamoto M.
  • Journal Title: J.Biochem. 147 Pages: 353-360
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• [Journal Article] NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation (2010)
  • Author(s): Motohashi H, Kimura M, Fujita R, Takayama M, Pan XQ, Katsuoka F, Aburatani H, Bresnick EH, Yamamoto M.
  • Journal Title: Blood 115 Pages: 677-686
  • Peer Reviewed
• [Journal Article] Keap 1 homodimer is a forked-stem structure with two large spheres en closing the intervening, double glycine repeat, and C-terminal domains (2010)
  • Author(s): Ogura T, Tong KI, Mio K, Maruyama Y, Kurokawa H, Sato C, Yamamoto M.
  • Journal Title: Proc Natl Acad Sci USA 107 Pages: 2842-2847
  • Peer Reviewed
• [Journal Article] Novel type of E3 ligase for Ufm 1-conjugating system (2010)
  • Author(s): Tatsumi K, Sou Y-S, Tada N, Nakamura E, Iemura S-i, Natsume T, Kang SH, Chung C H, Kasahara M, Kominami E, Yamamoto M, Tanaka K, Komatsu M.
  • Journal Title: J Biol Chem 285 Pages: 5417-5427
  • Peer Reviewed
• [Journal Article] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 (2010)
  • Author(s): Komatsu, M., Kurokawa, H., Waguri, S., Taguchi, K., Kobayashi, A., Ichimura, Y., Sou, Y.S., Ueno, I., Sakamoto, A., Tong, K.I., Kim, M., Nishito, Y., Iemura, S., Natsume, T., Ueno, T., Kominami, E., Motohashi, H., Tanaka, K., Yamamoto, M
  • Journal Title: Nat Cell Biol. 12 Pages: 213-223
  • Peer Reviewed
• [Journal Article] Deletion of Nuclear Factor-E2-Related Factor-2 Leads to Rapid Onset and Progression of Nutritional Steatohepatitis in Mice (2010)
  • Author(s): Sugimoto H, Okada K, Shoda J, Warabi E, Ishige K, Ueda T, Taguchi K, Yanagawa T, Nakahara A, Hyodo I, Ishii T, Yamamoto M.
  • Journal Title: Am J Physiol Gastrointest Liver Physiol 298 Pages: G283-G294
  • Peer Reviewed
• [Journal Article] Efficient transient rescue of hematopoietic mutant phenotypes in zebrafish using To12-mediated transgenesis (2010)
  • Author(s): Takeuchi M, Kaneko H, Nishikawa K, Kawakami K, Yamamoto M, Kobayashi M.
  • Journal Title: Dev Growth Differ (未定, 印刷中)
  • Peer Reviewed
• [Journal Article] Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice (2009)
  • Author(s): Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP.
  • Journal Title: Journal of Immunology 18 Pages: 7264-7271
  • Peer Reviewed
• [Journal Article] Genetic versus chemoprotective activation of Nrf2 signaling : overlapping yet distinct gene expression profiles between Keap 1 knockout and trite rpenoid treated mice (2009)
  • Author(s): Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K, Yamamoto M, Williams CR, Liby KT, Sporn MB, Sutter TR, Kensler TW.
  • Journal Title: Carcinogenesis 30 Pages: 1024-1031
  • Peer Reviewed
• [Journal Article] Nrf2 enhances cell proliferation and resistance to anticancer drugs in human lung cancer (2009)
  • Author(s): Homma S, Ishii Y, Morishima Y, Yamadori T, Matsuno Y, Haraguchi N, Kikuchi N, Satoh H, Sakamoto T, Hizawa N, Itoh K, Yamamoto M.
  • Journal Title: Clin.Cancer Res. 15 Pages: 3423-3432
  • Peer Reviewed
• [Journal Article] Dietary sulforaphane-rich broccoli sprouts reduce colonization and attenuate gastritis in Helicobacter pylori-infected mice and humans (2009)
  • Author(s): Yanaka A, Fahey JW, Fukumoto A, Nakayama M, Inoue S, Zhang S, Tauchi M, Suzuki H, Hyodo I, Yamamoto M.
  • Journal Title: Cancer Prev.Res. 2 Pages: 353-360
  • Peer Reviewed
• [Journal Article] Transcription factor Nrf2 is protective during ischemic and nephrotoxic acute kidney injury in mice (2009)
  • Author(s): Liu M, Grigoryev DN, Crow MT, Haas M, Yamamoto M, Reddy SP, Rabb H.
  • Journal Title: Kidney International 76 Pages: 277-285
  • Peer Reviewed
• [Journal Article] Nrf2 protects against maladaptive cardiac responses to hemodynamic stress (2009)
  • Author(s): Li J, Ichikawa T, Villacorta L, Janicki JS, Brower GL, Yamamoto M, Cui T.
  • Journal Title: Arterioscler Thromb.Vasc.Biol. 29 Pages: 1843-1850
  • Peer Reviewed
• [Journal Article] Lansoprazole, a proton pump inhibitor, mediates anti-inflammatory effect in gastric mucosal cells through the induction of heme oxygenase-1 via activation of Nrf2 and oxidation of Keap 1 (2009)
  • Author(s): Takagi T, Naito Y, Okada H, Ishii T, Mizushima K, Akagiri S, Adachi S, Handa O, Kokura S, Ichikawa H, Itoh K, Yamamoto M, Hirofumi M, Yoshikawa T.
  • Journal Title: J.Pharmacol.Exp.Ther. 331 Pages: 255-264
  • Peer Reviewed
• [Journal Article] 1-Cyano-2, 3-epithiopropane is a novel plant-derived chemopreventive agent which induces cytoprotective genes that afford resistance against the genotoxic{alpha}, {beta}-unsaturated aldehyde acrolein (2009)
  • Author(s): Kelleher MO, McMahon M, Eggleston IM, Dixon MJ, Taguchi K, Yamamoto M, Hayes JD.
  • Journal Title: Carcinogenesis 30 Pages: 1754-1762
  • Peer Reviewed
• [Journal Article] The triterpenoid CDDO-Imidazolide confers potent protection against hyperoxic acute lung injury in mice (2009)
  • Author(s): Reddy NM, Suryanaraya V, Yates MS, Kleeberger SR, Hassoun PM, Yamamoto M, Liby KT, Sporn MB, Kensler TW, Reddy SP
  • Journal Title: Am J Respir Crit Care Med 180 Pages: 867-874
  • Peer Reviewed
• [Journal Article] Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-Imidazolide (2009)
  • Author(s): Shin S, Wakabayashi J, Yates MS, Wakabayashi N, Dolan PM, Aja S, Liby KT, Sporn MB, Yamamoto M, Kensler TW
  • Journal Title: Eur J Pharmacol 620 Pages: 138-144
  • Peer Reviewed
• [Journal Article] Nrf2 counteracts cholestatic liver injury via stimulation of hepatic defense systems (2009)
  • Author(s): Okada K, Shoda J, Taguchi K, Maher JM, Ishizaki K, Inoue Y, Ohtsuki M, Goto N, Sugimoto H, Utsunomiya H, Oda K, Warabi E, Ishii T, Yamamoto M.
  • Journal Title: Biochem Biophys Res Commun 389 Pages: 431-436
  • Peer Reviewed
• [Journal Article] nnate immunity against bacterial infection following hyperoxia exposure is impaired in NRF2-deficient mice (2009)
  • Author(s): Reddy NM, Suryanarayana V, Kalvakolanu DV, Yamamoto M, Kensler TW, Hassoun PM, Kleeberger SR, Reddy SP.
  • Journal Title: J.Immunology 183 Pages: 4601-4608
  • Peer Reviewed
• [Journal Article] Structural basis of alternative DNA recognition by Maf transcription factors (2009)
  • Author(s): Kurokawa H, Motohashi H, Sueno S, Kimura M, Takagawa H, Kanno Y, Yamamoto M, Tanaka T.
  • Journal Title: Mol.Cell.Biol. 29 Pages: 6232-6244
  • Peer Reviewed
• [Journal Article] Constitutively active aryl hydrocarbon receptor expressed in T cells increases immunization-induced IFN-γ production in mice but does not suppress Th2-cytokine production or antibody production (2009)
  • Author(s): Nohara K, Suzuki T, Ao K, Murai H, Miyamoto Y, Inouye K, Pan X, Motohashi H, Fujii-Kuriyama Y, Yamamoto M, Tohyama C.
  • Journal Title: Int.Immunol 21 Pages: 769-777
  • Peer Reviewed
• [Journal Article] Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease (2009)
  • Author(s): Rojo AI, Innamorato NG, Martin-Moreno AM, De Ceballos ML, Yamamoto M, Cuadrado A
  • Journal Title: Glia 58 Pages: 588-598
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 井上大輔、本橋ほづみ、山本雅之
  • Journal Title: 酸化ストレスと呼吸器疾患(先端医学社) Pages: 6-7
• [Presentation] Neuron-specific nrf1 knockout mice display neurodegeneration with nuclear accumulation of ubiquitin-positive proteins (2009)
  • Author(s): 突出貴子、宮坂知宏、溝呂木達也、大辻摩希子、井原康夫、高島明彦、深水昭吉、山本雅之、小林聡
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Nrf2 is degraded by Keap1-independent proteasome pathway in the absence of small Maf proteins (2009)
  • Author(s): 勝岡史城、中山博未、本橋ほづみ、山本雅之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] TGF-beta suppresses transcription of Heme Oxigenase-1 through induction of MafK and Bach1 (2009)
  • Author(s): 沖田結花里、鴨志田敦、鈴木裕之、伊東健、本橋ほづみ、五十嵐和彦、山本雅之、加藤光保
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] GFP transgenic zebrafish is a good tool to classify Nrf2 activators (2009)
  • Author(s): Li L, Nakajima N, Tusjita T, Yamamoto M, Kobayashi M
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Identification of the target genes of transcription factor NF-E2 p45 in megakaryocytes (2009)
  • Author(s): 藤田理恵、本橋ほづみ、油谷浩幸、山本雅之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Dietary phosphorus regulates the detoxificartion-regulated gene expression through the activation of nuclear factor erythroid 2-related factor 2(Nrf2)in small intestine (2009)
  • Author(s): 浦川千鶴、山本浩範、竹井悠一郎、竹谷豊、山本雅之、武田英二
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] An easy and effective approach to rescue zebrafish mutant phenotypesvia transient transgenesis using Tol2 constructs (2009)
  • Author(s): Takeuchi M, Kaneko H, Nishikawa K, Kawakami K, Yamamoto M, Kobayashi M
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Identification of Nrf2-regulated genes in zebrafish (2009)
  • Author(s): Nakajima H, Nakajima-Takagi Y, Akiyama S, Wakasa T, Li L, Tsujita T, Kaneko H, Tamaru Y, Yamamoto M, Kobayashi M
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] A zebrafish model for human congenital disorder of glycosylation (2009)
  • Author(s): Mukaigasa K, Li L, Yagi H, Tsujita T, Kato K, Yamamoto M, Kobayashi M
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Comprehensive analysis of gene expression in central nervous system of small Maf compound mutant mice (2009)
  • Author(s): 弘津陽介、勝岡史城、山本雅之
  • Organizer: 第32回日本分子生物学会年会
  • Place of Presentation: 横浜
  • Year and Date: 2009-12-09
• [Presentation] Pivotal roles of small Maf proteins in the regulation of stress response genes (2009)
  • Author(s): Katsuoka F, Motohashi H, Nakayama H, Yamamoto M
  • Organizer: The 1st International Symposium "Challenge to Medical Innovation"
  • Place of Presentation: 仙台
  • Year and Date: 2009-12-07
• [Presentation] Luminal alkalization attenuates superoxide production induced by fatty acid-bound albumin in renal proximal tubular cells through Pyk2-dependent pathways (2009)
  • Author(s): Souma T, Abe M, Moriguchi T, Akiyama Y, Toyohara T, Shiwaku H, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S
  • Organizer: The 1st International Symposium "Challenge to Medical Innovation"
  • Place of Presentation: 仙台
  • Year and Date: 2009-12-07
• [Presentation] Structural basis of alternative DNA recognition by Maf transcription factors (2009)
  • Author(s): 黒河博文
  • Organizer: The 1st International Symposium "Challenge to Medical Innovation"
  • Place of Presentation: 仙台
  • Year and Date: 2009-12-07
• [Presentation] Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Development (2009)
  • Author(s): Kawatani Y, Suzuki T, Shimizu R, Kelly V, Yamamoto M.
  • Organizer: The 51th ASH Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-12-05
• [Presentation] Rescue of Erythropoietin-Deficient Mice From Anemia by Complementation with BAC Transgene (2009)
  • Author(s): Shun Yamazaki, Norio Suzuki, Naoshi Obara, Xiaoqing Pan, Ikuo Hirano, Kou-ichi Jishage, Kurisu Honda, Naoko Minegishi, Masayuki Yamamoto
  • Organizer: The 51th ASH Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2009-12-05
• [Presentation] 尿細管管腔内アルカリ化は脂肪酸結合アルブミンによる近位尿細管細胞からの活性酸素産生を、Pyk2経路を介して改善する。 (2009)
  • Author(s): 相馬友和、阿部倫明、森口尚、秋山泰利、豊原敬文、鈴木健弘、種本雅之、阿部高明、山本雅之、伊藤貞嘉
  • Organizer: Kidney Frontier 2009
  • Place of Presentation: 東京
  • Year and Date: 2009-11-28
• [Presentation] Nrf2-Keap1環境応答系機能の分子・構造基盤 (2009)
  • Author(s): 山本雅之
  • Organizer: 蛋白研セミナー「活性酸素のシグナル伝達」
  • Place of Presentation: 大阪
  • Year and Date: 2009-11-27
• [Presentation] Molecular Basis of Oxidative Stress Response (2009)
  • Author(s): 山本雅之
  • Organizer: International Symposium on Inflammation and Redox Signaling
  • Place of Presentation: Seoul National University Korea
  • Year and Date: 2009-11-21
• [Presentation] 116.The Nrf2-Keap1 system and cancer chemoprevention (2009)
  • Author(s): 山本雅之
  • Organizer: Special seminar at the Korean Society of Cancer Prevention, Lee Gil Ya Cancer and Diabetes Institute
  • Place of Presentation: Incheon, Korea
  • Year and Date: 2009-11-20
• [Presentation] Structural Basis of Nrf2-Keap1 Function (2009)
  • Author(s): 山本雅之
  • Organizer: Dasan 2009 Conferece on Bioremodelling
  • Place of Presentation: Jeju, Korea
  • Year and Date: 2009-11-18
• [Presentation] The Nrf2-Keap1 System and Cancer (2009)
  • Author(s): 山本雅之
  • Organizer: 第20回アジア太平洋癌学会/第18回日本腎泌尿器疾患予防医学研究会
  • Place of Presentation: つくば
  • Year and Date: 2009-11-12
• [Presentation] エリスロポエチンの産生細胞と発現制御 (2009)
  • Author(s): 山本雅之
  • Organizer: 第5回長時間透析研究会ランチョンセミナー
  • Place of Presentation: 横浜
  • Year and Date: 2009-11-08
• [Presentation] エリスロポエチン遺伝子の発現調節メカニズム (2009)
  • Author(s): 山本雅之
  • Organizer: 第18回 腎とエリスロポエチン研究会
  • Place of Presentation: 品川
  • Year and Date: 2009-11-07
• [Presentation] 環境応答転写因子群と炎症・アレルギー (2009)
  • Author(s): 山本雅之
  • Organizer: 第59回 日本アレルギー学会秋季学術大会特別企画シンポジウム2
  • Place of Presentation: 秋田
  • Year and Date: 2009-10-29
• [Presentation] Cell tyte-specific Nrf2 activation : different feature in hepatocytes and epithelial cells (2009)
  • Author(s): Taguchi K, Yamamoto M.
  • Organizer: CDBIM symposium
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] Nrf2 is degraded by Keap1-independent degradation pathway in the absence of small Maf proteins (2009)
  • Author(s): Fumiki Katsuoka, Hozumi Motohashi, Hiromi Nakayama, Masayuki Yamamoto
  • Organizer: CDBIM symposium
  • Place of Presentation: 東京
  • Year and Date: 2009-10-26
• [Presentation] 含セレン蛋白質とNrf2による酸化ストレスに対する2段階防御 (2009)
  • Author(s): 鈴木隆史、川谷幸恵、Vincent Kelly、山本雅之
  • Organizer: 第82回 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] 含セレン蛋白質とNrf2による2段階生体防御機構 (2009)
  • Author(s): 鈴木隆史、川谷幸恵、Vincent Kelly、山本雅之
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] マウス胎生期における小Maf群因子の機能 中山博未、勝岡史城、本橋ほづみ、山本雅之 (2009)
  • Author(s): 中山博未、勝岡史城、本橋ほづみ、山本雅之
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] 遺伝子欠失マウスのレスキューと条件付きEpo遺伝子破壊マウスの樹立 (2009)
  • Author(s): 山嵜瞬, 鈴木教郎, 小原直, 潘小青, 平野育生, 峯岸直子, 山本雅之
  • Organizer: 第82回日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-21
• [Presentation] The Nrf2-Keap1 System and Environmental Stress Response (2009)
  • Author(s): 山本雅之
  • Organizer: Symposium on "Comparative Animal Models of Leukemia and Lymphoma" at 14th International Association for Comparative Research on Leukemia and Related Diseases(IACRLRD)
  • Place of Presentation: The Ohio State University USA
  • Year and Date: 2009-10-14
• [Presentation] Nrf2-Keap1系と発癌 (2009)
  • Author(s): 山本雅之
  • Organizer: 第68回 日本癌学会学術総会 モーニングレクチャー
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Nrf2 acts as a novel metastasis suppressor in the lung (2009)
  • Author(s): Satoh H, Taguchi K, Moriguchi T, Suzuki T, Ebina M, Nukiwa T, Yamamoto M.
  • Organizer: 68回日本癌学会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-01
• [Presentation] Structural Basis of Sensor System for Cytoprotective Gene Expression Responding to Carcinogens and Oxidative Stress (2009)
  • Author(s): 黒河博文
  • Organizer: Cancer Science Institute of Singapore(CSI)-NMGCOE Joint Workshop
  • Place of Presentation: Cancer Science Institute of Singapore
  • Year and Date: 2009-09-09
• [Presentation] Functional significance of N-terminal region of transcription factor NF-E 2 p45 in thrombogenesis (2009)
  • Author(s): 高山昌理子
  • Organizer: 第10回文部科学省特定領域研究「がん」5領域 若手研究者ワークショップ
  • Place of Presentation: 新潟
  • Year and Date: 2009-09-02
• [Presentation] 発癌性物質や酸化ストレスに応答する生体防御系センサーの構造基盤 (2009)
  • Author(s): 黒河博文
  • Organizer: ターゲットタンパク研究プログラム 第3回全体交流会
  • Place of Presentation: 京都
  • Year and Date: 2009-08-31
• [Presentation] Nrf2-Keap1システムと肺疾患 (2009)
  • Author(s): 山本雅之
  • Organizer: 第12回 質性肺炎細胞分子病態研究会「慢性炎症機序と呼吸器疾患」
  • Place of Presentation: 東京
  • Year and Date: 2009-08-22
• [Presentation] New function of host NRF2 in lung cancer (2009)
  • Author(s): 佐藤大希, 田口恵子, 森口尚, 鈴木隆史, 海老名雅仁, 貫和敏博, 山本雅之
  • Organizer: Interdisciplinary Force 学生成果発表会
  • Place of Presentation: 仙台
  • Year and Date: 2009-08-04
• [Presentation] Regulation of erythropoietin gene expression in mouse (2009)
  • Author(s): Masayuki Yamamoto, Xiaoqing Pan, Syun Yamazaki, Ikuo Hirano, Naoko Minegishi, Norio Suzuki
  • Organizer: 8th International Luebeck Conference on the Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Growth Factors
  • Place of Presentation: University of Luebeck Germany
  • Year and Date: 2009-07-30
• [Presentation] Roles of HIF-binding sequences in chromatin dynamics during activation of the hypoxia-inducible genes (2009)
  • Author(s): Norio Suzuki, Orjan Wrange, Katarina Gradin, Sergey Belikov, Kian Leong Lee, Masayuki Yamamoto, Lorenz Poellinger
  • Organizer: 8th Int.Luebeck Conference Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Growth Factors
  • Place of Presentation: University of Luebeck, Germany
  • Year and Date: 2009-07-30
• [Presentation] Localization and expression pattern of erythropoietin producing cells in the adult and developing mouse retina (2009)
  • Author(s): N.Scheerer, N.Dunker, S.Imagawa, M.Yamamoto, N.Suzuki, J.
  • Organizer: 8th Int.Luebeck Conference Pathophysiology and Pharmacology of Erythropoietin and other Hemopoietic Growth Factors
  • Place of Presentation: University of Luebeck, Germany
  • Year and Date: 2009-07-30
• [Presentation] The Nrf2-Keap1 system and oxidative stress response (2009)
  • Author(s): 山本雅之
  • Organizer: International Symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: 阿蘇
  • Year and Date: 2009-07-18
• [Presentation] Select heterozygous Keap1 mutations have a dominant-negative effect on wildtype Keap1 in vivo (2009)
  • Author(s): Takafumi Suzuki, Jonathan Maher, Yukie Kawatani, Masayuki Yamamoto
  • Organizer: International symposium 2009 on Signaling Functions of Reactive Oxygen Species
  • Place of Presentation: 阿蘇
  • Year and Date: 2009-07-18
• [Presentation] Nrf2-Keap1システムと肺発癌の関係 (2009)
  • Author(s): 佐藤大希
  • Organizer: 医学薬学合同セミナー
  • Place of Presentation: 仙台
  • Year and Date: 2009-07-16
• [Presentation] 酸化ストレス応答と発癌 (2009)
  • Author(s): 山本雅之
  • Organizer: 宮城県立がんセンターセミナー
  • Place of Presentation: 仙台
  • Year and Date: 2009-07-15
• [Presentation] Keap1-Nrf2システムの多様な感知応答機構 (2009)
  • Author(s): 李麗、中島瞳、中島やえこ、岩本典子、熊谷嘉人、山本雅之、小林麻己人
  • Organizer: 平成21年度日本生化学会関東支部例会「若手が担う次世代型生化学研究」
  • Place of Presentation: つくば
  • Year and Date: 2009-06-20
• [Presentation] ヒト先天性グリコシル化異常症の病態モデルゼブラフィッシュの解析 (2009)
  • Author(s): 向笠勝貴、辻田忠志、李麗、山本雅之、小林麻己人
  • Organizer: 平成21年度日本生化学会関東支部例会「若手が担う次世代型生化学研究」
  • Place of Presentation: つくば
  • Year and Date: 2009-06-20
• [Presentation] エリスロポエチン遺伝子発現制御に十分な領域 (2009)
  • Author(s): 山崎瞬, 鈴木教郎, 小原直, 潘小青, 平野育生, 峯岸直子, 山本雅之
  • Organizer: 東北大学バイオサイエンスシンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-06-16
• [Presentation] Nrf2誘導剤スクリーニング系の確立 (2009)
  • Author(s): 弘津陽介、勝岡史城、山本雅之
  • Organizer: 平成21年度合同班会議「遺伝子情報デコード」
  • Place of Presentation: 富山
  • Year and Date: 2009-06-14
• [Presentation] 環境適応・応答の分子機構 (2009)
  • Author(s): 山本雅之
  • Organizer: 第18回 翠嶂会・近畿大学大学院医学研究科ハイテクリサーチセンター合同公開シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 2009-06-13
• [Presentation] 含セレン蛋白質とNrf2による2段階生体防御機構 (2009)
  • Author(s): 鈴木隆史、川谷幸恵、Vincent Kelly、山本雅之
  • Organizer: 第62回 日本酸化ストレス学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-06-11
• [Presentation] 環境ストレス応答と化学発癌の分子メカニズム (2009)
  • Author(s): 山本雅之
  • Organizer: 弘前大学セミナー
  • Place of Presentation: 弘前
  • Year and Date: 2009-05-28
• [Presentation] Genetically induced ER stress in a zebrafish model for human congenital disorders of glycosylation (2009)
  • Author(s): Mukaigasa, K., Li, L., Tsujita, T., Yamamoto, M., Kobayashi, M.
  • Organizer: 日本発生生物学会第42回大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-28
• [Presentation] Mutation of the lysine-specific demethylase 1 gene causes lineage-specific defects in zebrafish hematopoiesis (2009)
  • Author(s): Takeuchi, M., Kaneko, H., Kobayashi, M., Yamamoto, M.
  • Organizer: 日本発生生物学会第42回大会
  • Place of Presentation: 新潟
  • Year and Date: 2009-05-28
• [Presentation] 環境応答転写因子 (2009)
  • Author(s): 山本雅之
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-22
• [Presentation] Nrf2-Keap1系の分子構造基盤と発癌 (2009)
  • Author(s): 山本雅之
  • Organizer: 第9回 日本蛋白質科学会年会シンポジウム
  • Place of Presentation: 熊本
  • Year and Date: 2009-05-20
• [Presentation] マウス胎生期における小Maf群因子の機能 (2009)
  • Author(s): 勝岡史城、中山博未、本橋ほづみ、Engel JD, 山本雅之
  • Organizer: 日本生化学会東北支部 第75回例会・シンポジウム
  • Place of Presentation: 仙台
  • Year and Date: 2009-05-09
• [Presentation] Molecular basis for the Nrf2-Keap1 system function (2009)
  • Author(s): 山本雅之
  • Organizer: Experimental Biology 2009
  • Place of Presentation: New Orleans, LA, USA
  • Year and Date: 2009-04-18
• [Presentation] 酸化ストレス応答と病態 (2009)
  • Author(s): 山本雅之
  • Organizer: 第7回Vascular and Brain Conference
  • Place of Presentation: 大阪
  • Year and Date: 2009-04-09