酸素や食物が内包する毒性に対する細胞の適応・応答の分子機構の解明

2010 Fiscal Year Annual Research Report

• Project/Area Number: 19GS0312
• Research Institution: Tohoku University
• Principal Investigator: 山本 雅之 東北大学, 大学院・医学系研究科, 教授 (50166823)
• Co-Investigator(Kenkyū-buntansha): 勝岡 史城 東北大学, 大学院・医学系研究科, 准教授 (30447255)
• Keywords: Nrf2 / Keap1 / 酸化ストレス / 低酸素 / エリスロポエチン

Research Abstract

生体は、環境ストレスに適切に応答して恒常性を維持している。本研究は、生体がストレスを感知するセンサーの分子機構とストレスによって惹起される生体防御機構の解明を目的としている。
Nrf2-Keap1システムによるストレス感知機構および同システムと発癌との関連性の解析:構造学的解析により、酸化ストレス感知に重要なシステイン151を含むKeap1 BTBドメインの結晶構造を明らかにした。トランスジェニック(TG)マウスを用いた解析では、二量体化部位に変異を持つKeap1を発現するマウスにおいて、Nrf2が恒常的に活性化することを示し、Keap1二量体化がNrf2抑制に必須であることを個体レベルで実証した。また、Nrf2との結合部位に変異を有するKeaplと野性型Keap1の二量体にはNrf2抑制能がないことが示し、がん細胞ではKeaplヘテロ型変異によっても恒常的なNrf2活性化が起こり、がん悪性化に寄与していること示した。
エリスロポエチン(Epo)遺伝子制御機構と低酸素感知機構の解析:Epo遺伝子制御領域下で緑色蛍光タンパク質(GFP)を発現するマウスの腎臓からGFP陽性細胞を単離する方法を改良し、これまでの5～10倍の効率で腎Epo産生細胞を得ることに成功した。得られた細胞を用いて、生体外での増幅や株化の条件を検討している。また、これまでに同定した肝臓の制御領域のみでEpo遺伝子を発現するTGマウスを作製し、Epo遺伝子欠損マウスのレスキュー解析を実施した。この過程でおいて、生存・繁殖は可能であるが、重度の貧血症状を示すマウス系統が得られ、腎性貧血モデルマウスとして樹立した。各臓器への酸素供給能が低いこのマウスを用いることで、恒常的な低酸素状態がもたらす個体の代謝機能の変化についての解析を進めている。

Research Products

• [Journal Article] Nrf2 degron-fused reporter system ; a new tool for specific evaluation of Nrf2 inducers (2011)
  • Author(s): Hirotsu Y, Katsuoka F, Itoh K, Yamamoto M
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• [Journal Article] Inducible disruption of autophagy in the lung causes airway hyper-responsiveness (2011)
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• [Journal Article] Nrf2 and selenoproteins are essential for maintaining oxidative homeostasis in erythrocytes and protecting against hemolytic anemia (2011)
  • Author(s): Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M
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  • DOI: 10.1182/blood-2010-05-285817
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• [Journal Article] Molecular determinants for small Maf protein control of platelet production (2011)
  • Author(s): Motohashi H, Fujita R, Takayama M, Inoue A, Katsuoka F, Bresnick EH, Yamamoto M
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  • DOI: 10.1128/MCB.00798-10
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• [Journal Article] Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution (2011)
  • Author(s): Taguchi K, Motohashi H, Yamamoto M
  • Journal Title: Genes Cells Volume: 16 Pages: 123-140
  • DOI: 10.1111/j.1365-2443.2010.01473.x
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• [Journal Article] The Ufm1-activating enzyme Uba5 is indispensable for erythroid differentiation in mice (2011)
  • Author(s): Tatsumi K, Yamamoto-Mukai H, Shimizu R, Waguri S, Sou Y-S, Sakamoto A, Taya C, Shitara H, Hara T, Chung CH, Tanaka K, Yamamoto M, Komatsu M
  • Journal Title: Nature Commun Volume: 2 Pages: 181
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• [Journal Article] Protein aggregation, not polyubiquitin conjugation, serves as a signal for selective autophagy (2011)
  • Author(s): Riley BE, Kaiser SE, Shaler TA, Hara T, Hipp MS, Sofos E, Ng ACY, Lage K, Xavier RJ, Ryu K-Y, Yamamoto M, Ishii T, Tanaka K, Mizushima N, Komatsu M, Kopito RR
  • Journal Title: J Cell Biol Volume: 191 Pages: 537-552
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• [Journal Article] Luminal alkalization attenuates superoxide production induced by fatty acid-bound albumin in renal proximal tubular cells through Pyk2-dependent pathways (2011)
  • Author(s): Souma T, Abe M, Moriguchi T, Yanagisawa-Miyazawa N, Shibata E, Akiyama Y, Toyohara T, Suzuki T, Tanemoto M, Abe T, Sato H, Yamamoto M, Ito S
  • Journal Title: J Am Soc Nephrol Volume: (未定)(印刷中)
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• [Journal Article] CD36 participates in a signaling pathway that regulates ROS formation in murine VSMC (2011)
  • Author(s): Li W, Febbraio M, Reddy SP, Yu D-Y, Yamamoto M, Silverstein RL
  • Journal Title: J Clin Invest Volume: 120 Pages: 3996-4006
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• [Journal Article] Differential Modulation of Keratin Expression by Sulforaphane Occurs via Differential Modulation of Keratin Expression by Sulforaphane Occurs via Nrf2-dependent and -independent Pathways in Skin Epithelia (2011)
  • Author(s): Kerns M, Depianto D, Yamamoto M, Coulombe PA
  • Journal Title: Mol Biol Cell Volume: 23 Pages: 4068-4057
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• [Journal Article] Possible Involvement of Oxidative Stress in 5-Fluorouracil-Mediated Myelosuppression in Mice (2011)
  • Author(s): Numazawa S, Sugihara K, Miyake S, Tomiyama H, Hida A, Hatsuno M, Yamamoto M, Yoshida T
  • Journal Title: Basic Clin Pharmacol Toxicol Volume: 108 Pages: 40-45
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• [Journal Article] Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system : study using GFP transgenic zebrafish (2011)
  • Author(s): Tsujita T, Li L, Nakajima H, Nakajima-Takagi Y, Kawakami K, Freeman B, Yamamoto M, Kobayashi M
  • Journal Title: Genes Cells Volume: 16 Pages: 46-57
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• [Journal Article] Central nervous system-specific deletion of transcription factor Nrf1 causes progressive motor neuronal dysfunction (2011)
  • Author(s): Akira Kobayashi, Takako Tsukide, Tomohiro Miyasaka, Tomoko Morita, Tatsuya Mizoroki, Yoshiro Saito, Yasuo Ihara, Akihiko Takashima, Noriko Noguchi, Akiyoshi Fukamizu, Yosuke Hirotsu, Makiko Ohtsuji, Fumiki Katsuoka, Masayuki Yamamoto
  • Journal Title: Genes Cells Volume: (未定)(印刷中)
  • Peer Reviewed
• [Journal Article] Discovery of the negative regulator of Nrf2, Keap1 : A historical overview (2011)
  • Author(s): Itoh K, Mimura J, Yamamoto M
  • Journal Title: Antioxid Redox Signal Volume: 13 Pages: 1665-1678
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• [Journal Article] Global downstream pathway analysis reveals a dependence of oncogenic NF-E2-related factor 2 mutation on the mTOR growth signaling pathway (2010)
  • Author(s): Shibata T, Saito S, Kokubu A, Suzuki T, Yamamoto M, Hirohashi S
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• [Journal Article] Regulation of Notch1 signaling by Nrf2 : Implications for tissue regeneration (2010)
  • Author(s): Wakabayashi N, Shin S, Slocum SL, Agoston ES, Wakabayashi J, Kwak M-K, Misra V, Biswal S, Yamamoto M, Kensler TW
  • Journal Title: Science Signaling Volume: 3 Pages: 1-11
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• [Journal Article] Aggressive mammary carcinoma progression in Nrf2 knockout mice treated with 7,12-dimethylbenz[a]anthracene (2010)
  • Author(s): Becks L, Prince M, Burson H, Christophe C, Broadway M, Itoh K, Yamamoto M, Mathis M, Orchard E, Shi R, McLarty J, Pruitt K, Zhang S, Kleiner-Hancock HE
  • Journal Title: BMC Cancer Volume: 10 Pages: 540-556
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• [Journal Article] Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice (2010)
  • Author(s): Li YJ, Takizawa H, Azuma A, Kohyama T, Yamauchi Y, Takahashi S, Yamamoto M, Kawada T, Kudoh S, Sugawara I
  • Journal Title: Clin Immunol Volume: 137 Pages: 234-241
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• [Journal Article] Suppression of SLC11A2 Expression is essential to maintain duodenal integrity during dietary iron overload (2010)
  • Author(s): Shirase T, Mori K, Okazaki Y, Itoh K, Yamamoto M, Tabuchi M, Kishi F, Jiang L, Akatsuka S, Nakao K, Toyokuni S
  • Journal Title: Am J Pathol Volume: 177 Pages: 677-685
  • Peer Reviewed
• [Journal Article] Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung (2010)
  • Author(s): Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T, Yamamoto M
  • Journal Title: Carcinogenesis Volume: 31 Pages: 1833-1843
  • Peer Reviewed
• [Journal Article] The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response (2010)
  • Author(s): Fujii S, Sawa T, Ihara H, Tong KI, Ida T, Okamoto T, Ahtesham AK, Ishima Y, Motohashi H, Yamamoto M, Akaike T
  • Journal Title: J Biol Chem Volume: 285 Pages: 23970-23984
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• [Journal Article] The anemia of the newborn induces erythropoietin expression in the developing mouse retina (2010)
  • Author(s): Scheerer N, Dunker N, Imagawa S, Yamamoto M, Suzuki N, Fandrey J., The anemia of the newborn induces erythropoietin expression in the developing mouse retina
  • Journal Title: Am J Physiol Regul Integr Comp Physiol Volume: 299 Pages: R111-R118
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• [Journal Article] Ischemia-Induced Neovascularization by Enhancing the Inflammatory Response (2010)
  • Author(s): Ichihara S, Yamada Y, Liu F, Murohara T, Itoh K, Yamamoto M, Ichihara G
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 30 Pages: 1553-1556
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• [Journal Article] The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathway (2010)
  • Author(s): Shah ZA, Li RC, Ahmad AS, Kensler TW, Yamamoto M, Biswal S, Dore S
  • Journal Title: J Cereb Blood Flow Metab Volume: 30 Pages: 1951-1961
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• [Journal Article] Genetic analysis of cytoprotective functions supported by graded expression of Keap1 (2010)
  • Author(s): Taguchi K, Maher J, Suzuki T, Kawatani Y, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol Volume: 30 Pages: 3016-3026
  • Peer Reviewed
• [Journal Article] Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver (2010)
  • Author(s): Lamsa V, Levonen AL, Leinonen H, Yla-Herttuala S, Yamamoto M, Hakkola J
  • Journal Title: Chem Res Toxicol Volume: 23 Pages: 977-985
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• [Journal Article] Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defense and lipid metabolism as primary Nrf2-dependent pathways in the liver (2010)
  • Author(s): Kitteringham NR, Abdullah A, Walsh J, Randle L, Jenkins RE, Sison R, Goldring CE, Sanderson C, Williams S, Higgins L, Yamamoto M, Hayes J, Park BK
  • Journal Title: J Proteomics Volume: 73 Pages: 1612-1631
  • Peer Reviewed
• [Journal Article] Genetic analysis of hierarchical regulation for Gatal and NF-E2 p45 gene expression in megakaryopoiesis (2010)
  • Author(s): Takayama M, Fujita R, Suzuki M, Okuyama R, Aiba S, Motohashi H, Yamamoto M
  • Journal Title: Mol Cell Biol Volume: 30 Pages: 2668-2680
  • Peer Reviewed
• [Journal Article] Increased susceptibility of Nrf2 null mice to 1-bromopropane-induced hepatotoxicity (2010)
  • Author(s): Liu F, Ichihara S, Valentine WM, Itoh K, Yamamoto M, Mohideen SS, Kitoh J, Ichihara G
  • Journal Title: Toxicol Sci Volume: 115 Pages: 596-606
  • Peer Reviewed
• [Journal Article] Role of Nrf2 in retinal vascular development and the vaso-obliterative phase of oxygen-induced retinopathy (2010)
  • Author(s): Uno K, Prow TW, Bhutto IA, Yerrapureddy A, McLeod DS, Yamamoto M, Reddy SP, Lutty GA
  • Journal Title: Exp Eye Res Volume: 90 Pages: 493-500
  • Peer Reviewed
• [Journal Article] Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance (2010)
  • Author(s): Kikuchi N, Ishii Y, Morishima Y, Yageta Y, Haraguchi N, Itoh K, Yamamoto M, Hizawa N., Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance
  • Journal Title: Respir Res Volume: 11 Pages: 31-42
  • Peer Reviewed
• [Journal Article] The transcriptome of Nrf2^<-/-> Mice provides evidence for impaired cell cycle progression in the development of cigarette-smoke-induced emphysematous changes (2010)
  • Author(s): Gebel S, Diehl S, Pype J, Friedrichs B, Weiler H, Schuller J, Xu H, Taguchi K, Yamamoto M, Muller T
  • Journal Title: Tox Sci Volume: 115 Pages: 238-252
  • Peer Reviewed
• [Journal Article] Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo (2010)
  • Author(s): Suzuki T, Maher J, Yamamoto M
  • Journal Title: Cancer Res Volume: 71 Pages: 1700-1709
  • Peer Reviewed
• [Journal Article] The rise of antioxidant signaling-the evolution and hormetic actions of Nrf2 (2010)
  • Author(s): Maher J, Yamamoto M
  • Journal Title: Antioxidant Redox Biol Volume: 244 Pages: 4-15
  • Peer Reviewed
• [Presentation] Stress response of megakaryocytes alters inherent reactivity of platelets (2010)
  • Author(s): Hozumi Motohashi, Rie Fujita, Hironori Satoh, Hiroyuki Aburatani, Masayuki Yamamoto
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] 成獣における誘導的エリスロポエチン遺伝子破壊の造血に与える影響 (2010)
  • Author(s): 山嵜瞬、峯岸直子、鈴木教郎、小原直、潘小青、平野育生、寺社下浩一、本田紅里穂、山本雅之
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] 単離腎臓Erythropoietin産生細胞を用いたErythropoietin遺伝子制御機構の解明 (2010)
  • Author(s): 平野育生、潘小青、鈴木教郎、山嵜瞬、小原直、峯岸直子、山本雅之
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] ニトロ化環状ヌクレオチドによるタンパク質S-グアニル化を介する酸化ストレス適応応答の分子機序 (2010)
  • Author(s): 藤井重元、澤智裕、居原秀、Kit I Tong、井田智章、岡本竜哉、Ahmed Khandaker Ahtesham、本橋ほづみ、山本雅之、赤池孝章
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Regulation of platelet reactivity by transcription factor NF-E2 p45 in megakaryocytes (2010)
  • Author(s): 藤田理恵、高山昌理子、本橋ほづみ、山本雅之
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] Cytoplasmic and nuclear degradation mechanisms regulate biological function of the transcription factor Nrf1 (2010)
  • Author(s): 森田智子, 土谷佳樹, 金美姫, 家村俊一郎, 突出貴子, 夏目徹, 山本雅之, 小林聡
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] 転写因子Nrf1とNrf2の中枢神経系における機能的差異の検証 (2010)
  • Author(s): 弘津陽介, 勝岡史城, 小林聡, 山本雅之
  • Organizer: 第33回日本分子生物学会年会・第83回日本生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-07
• [Presentation] 生体のストレス応答の分子基盤 (2010)
  • Author(s): 山本雅之
  • Organizer: 日本抗加齢医学会研修/更新用講習会
  • Place of Presentation: 東京
  • Year and Date: 2010-12-05
• [Presentation] 酸素と医学 (2010)
  • Author(s): 山本雅之
  • Organizer: 創生応用医学研究会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-27
• [Presentation] EPO研究のフロンティアと新しいEPOの可能性 (2010)
  • Author(s): 山本雅之
  • Organizer: 第19回腎とエリスロポエチン研究会
  • Place of Presentation: 品川
  • Year and Date: 2010-11-21
• [Presentation] エリスロポエチン産生細胞(Erythropoietin Producing Cells) (2010)
  • Author(s): 山本雅之
  • Organizer: 第74回日本皮膚科学会学術大会
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-21
• [Presentation] Embryonic lethality and fetal liver hypoplasia in mice lacking all three small Maf proteins (2010)
  • Author(s): Fumiki Katsuoka, Hiromi Yamazaki, Hozumi Motohashi, James Douglas Engel, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society (JBS) Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-17
• [Presentation] Functional Roles of NF-E2 p45 in the Regulation of Platelet Activity (2010)
  • Author(s): Rie Fujita, Mariko Takayama-Tsujimoto, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-17
• [Presentation] Analysis of the Role of Nrf2-Keap1 System in Hematopoietic Stem Cell (2010)
  • Author(s): Shohei Murakami, Hozumi Motohashi, Masayuki Yamamoto
  • Organizer: 9th Japanese Biochemical Society Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-17
• [Presentation] Erythropoietin from neural and neural crest cells support primitive erythropoiesis (2010)
  • Author(s): Hirano I, Suzuki N, Pan X, Minegishi N, Yamamoto M
  • Organizer: 9th Japanese Biochemical Society Bio-frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-17
• [Presentation] Isolation and characterization of renal erythropoietin-producing cells : Contribution of HIF3a in vivo (2010)
  • Author(s): Pan X, Suzuki N, Hirano I, Yamazaki S, Yamashita T, Ohneda O, Minegishi N, Yamamoto M
  • Organizer: 9th Japanese Biochemical Society Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-17
• [Presentation] Rescue of Epo-deficient mice from anemia by complementation with BAC transgene (2010)
  • Author(s): Yamazaki S, Suzuki N, Obara N, Pan X, Hirano I, Jishage K, Honda C, Minegishi N, Yamamoto M
  • Organizer: 9th Japanese Biochemical Society Bio-Frontier Symposium 2010/5th International Symposium on GATA factors
  • Place of Presentation: 仙台
  • Year and Date: 2010-11-17
• [Presentation] 発癌性物質や酸化ストレスに応答する生体防御系センサーの構造基盤 (2010)
  • Author(s): 黒河博文、本橋ほづみ、佐藤主税、山本雅之
  • Organizer: ターゲットタンパク研究プログラム平成22年度成果発表会
  • Place of Presentation: 東京
  • Year and Date: 2010-10-20
• [Presentation] Molecular basis of CNC and small Maf dimer function in neural tissues (2010)
  • Author(s): Fumiki Katsuoka
  • Organizer: Jornada Cientifica-Regulatory mechanisms in inflammatory processes
  • Place of Presentation: スペイン、バレンシア
  • Year and Date: 2010-10-15
• [Presentation] 酸化ストレス応答の分子基盤 (2010)
  • Author(s): 山本雅之
  • Organizer: 日本分子脳神経外科学会ランチョンセミナー
  • Place of Presentation: 仙台
  • Year and Date: 2010-09-22
• [Presentation] 宿主におけるNrf2欠損はMDSCs細胞に著明な酸化ストレスの蓄積を誘導し、肺癌転移に対して有利な微小環境を創造する (2010)
  • Author(s): 佐藤大希、森口尚、田口恵子、海老名雅仁、貫和敏博、山本雅之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 転写因子Nrf2はヒト肺線癌細胞株A549でosteopontinの発現を増加させる (2010)
  • Author(s): 光石陽一郎、本橋ほづみ、貫和敏博、山本雅之
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-22
• [Presentation] 環境応答の分子基盤 (2010)
  • Author(s): 山本雅之
  • Organizer: 平成22年度ターゲットタンパクプロジェクト産学懇談会
  • Place of Presentation: 東京
  • Year and Date: 2010-07-07
• [Presentation] Nrf2-Keap1 System and Respiratory Diseases (2010)
  • Author(s): Masayuki Yamamoto
  • Organizer: The 6th International Conference on the Biology, Chemistry, and Therapeutic Applications of Nitric Oxide
  • Place of Presentation: 京都
  • Year and Date: 2010-06-14
• [Presentation] 環境応答の分子基盤 (2010)
  • Author(s): 山本雅之
  • Organizer: 分子生物学会第10回春季シンポジウム
  • Place of Presentation: 松島
  • Year and Date: 2010-06-08
• [Presentation] Keap1-Nrf2 system and cancer (2010)
  • Author(s): Masayuki Yamamoto
  • Organizer: Tuesday Special Seminar, Cancer Research Institute of Seoul National University
  • Place of Presentation: 韓国、ソウル
  • Year and Date: 2010-06-01
• [Presentation] Deletion of selenocysteine tRNA gene results in compensatory gene induction of cytoprotective enzymes by Nrf2 (2010)
  • Author(s): Takafumi Suzuki, Yukie Kawatani, Akira Ohkoshi, Vincent Kelly, Masayuki Yamamoto
  • Organizer: 9^<th> international Symposium on selenium in Biology and Medicine Selenium 2010
  • Place of Presentation: 京都
  • Year and Date: 2010-05-31
• [Presentation] Compound Deficiency of Nrf2 and Selenoproteins in Hematopoietic Cells Leads to Severe Defects in Erythroid and Lymphoid Lineage Development (2010)
  • Author(s): Kawatani Y, Suzuki T, Shimizu R, Kelly VP, Yamamoto M
  • Organizer: 9^<th> international Symposium on selenium in Biology and Medicine Selenium 2010
  • Place of Presentation: 京都
  • Year and Date: 2010-05-31
• [Presentation] Cytoprotective systems of skin by selenoproteins and Nrf2 (2010)
  • Author(s): Mariko Takayama, Takafumi Suzuki, Kai Takaya, Ryuhei Okuyama, Masayuki Yamamoto
  • Organizer: 9^<th> international Symposium on selenium in Biology and Medicine Selenium 2010
  • Place of Presentation: 京都
  • Year and Date: 2010-05-31
• [Presentation] エリスロポエチンの産生細胞と発現制御 (2010)
  • Author(s): 山本雅之
  • Organizer: 北陸エリスロポエチンフォーラム
  • Place of Presentation: 金沢
  • Year and Date: 2010-05-08
• [Presentation] 上皮細胞における転写因子Nrf2の活性化 (2010)
  • Author(s): 田口恵子、鈴木隆史、本橋ほづみ、山本雅之
  • Organizer: 日本生化学会東北支部会第76回例会・シンポジウム
  • Place of Presentation: 福島
  • Year and Date: 2010-05-08
• [Presentation] 転写因子Nrf2は宿主肺における癌転移抑制因子である (2010)
  • Author(s): 佐藤大希、田口恵子、森口尚、海老名雅仁、貫和敏博、山本雅之
  • Organizer: 第50回日本呼吸器学会学術総会
  • Place of Presentation: 湯沢
  • Year and Date: 2010-04-23
• [Book] Diabetes Frontier (2010)
  • Author(s): 宇留野晃、森口尚、山本雅之
  • Total Pages: 412-417
  • Publisher: メディカルレビュー社
• [Book] 腎と透析 (2010)
  • Author(s): 峯岸直子、山本雅之
  • Total Pages: 1607-1615
  • Publisher: 東京医学社