New bone implantology for seeking implants that does not cause bone degradation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H00827
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 26:Materials engineering and related fields
• Research Institution: University of Toyama (2021-2022); Osaka University (2019-2020)
• Principal Investigator: Ishimoto Takuya 富山大学, 学術研究部都市デザイン学系, 教授 (50508835)
• Co-Investigator(Kenkyū-buntansha): 中野 貴由 大阪大学, 工学研究科, 教授 (30243182)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: ひずみ遮蔽 / インプラント / 骨細胞（オステオサイト） / 骨質

Outline of Final Research Achievements

Important fundamental findings for development of implants without causing bone degradation due to strain shielding have been obtained. We found that osteocytes in bone exhibit anisotropy of morphology to efficiently sense the anisotropic strain field produced in bone, that when the anisotropy of the strain field is reduced, the anisotropy of osteocytes is also reduced and their ability to sense the anisotropic strain field is degraded, and that the resulting degradation of bone matrix orientation along the strain direction. In addition, it was found that not only bone resorption but also bone matrix orientation, which is newly formed under strain shielding, was originally degraded under the use of metal implant. In conclusion, we found that a strategy to avoid strain shielding as much as possible and to introduce a mechanism to actively load strain to the implant is indispensable to realize implants that maintain healthy bone.

Free Research Field

金属組織学、生体材料学

Academic Significance and Societal Importance of the Research Achievements

骨配向性を指標とすることで、インプラント埋入下での骨の強度が、骨の量的変化（骨密度の低下や骨萎縮）から予測される以上に劣化していることが明らかになった。インプラント開発が骨配向性に基づいて行われることで、骨の機能の劣化を本質的にもたらさないインプラントの獲得につながることが期待される。