Exploring of functional peptides from edible proteins and establishment of oral administration without activity loss

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H00837
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 27:Chemical engineering and related fields
• Research Institution: Nagoya University
• Principal Investigator: HONDA HIROYUKI 名古屋大学, 工学研究科, 教授 (70209328)
• Co-Investigator(Kenkyū-buntansha): 落合 秋人 新潟大学, 自然科学系, 准教授 (40588266) ; 長岡 利 岐阜大学, 応用生物科学部, 教授 (50202221) ; 谷口 正之 新潟大学, 自然科学系, 教授 (00163634)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: ペプチド / 可食性タンパク質 / 探索 / 腸輸送 / 情報解析

Outline of Final Research Achievements

Bioactive peptides with moderate length of 5 to 10-mer are potentially existing into the sequences of plentiful edible proteins. In oral administration of such peptides, development of direct delivery without hydrolysis to the intestine space is strongly desired in the field of healthcare, nutrition and cosmetics. In the present study, following 3 topics were investigated, 1) screening of meso-length bioactive peptides from plentiful edible protein by informational analysis, 2) establishment of selective separation and concentration method of such peptides by optimization of protease hydrolysis, and 3) development of direct delivery without hydrolysis to the intestine using heat treated porous silica gel which can adsorb bioactive peptides in inner space at acidic pH and can release them at neutral pH.

Free Research Field

生物機能工学

Academic Significance and Societal Importance of the Research Achievements

生理活性ペプチドが加水分解を受けずに腸内送達できる技術は、健康食品素材としてのペプチドの利用可能性を飛躍的に広げることができるため、食品企業等に及ぼす影響は大きい。物理化学的特性を利用した選択的吸着担体はペプチドの生理機能と物理化学的特性の関連性に踏み込んでおり、生理機能の理解という学術面での意義も高い。