Investigations and control of functional nanocomplexes in tumor environment

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H00857
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 28:Nano/micro science and related fields
• Research Institution: Japan Advanced Institute of Science and Technology
• Principal Investigator: Miyako Eijiro 北陸先端科学技術大学院大学, 先端科学技術研究科, 准教授 (70443231)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ナノ粒子 / がん / ドラッグデリバリー / レーザー / ナノテクノロジー

Outline of Final Research Achievements

Due to their unique characteristics, gallium-based liquid metal (LM) nanoparticles have been applied in various research fields. LM nanoparticle surface-modification design is essential for enhancing the original LM properties and physicochemical multifunctionalization. Besides, standard cancer treatments are currently limited to surgery, radiation, and chemotherapy. Unfortunately, all three methods risk damage to normal tissues or incomplete eradication of the cancer. Development of LM-based nanomedicinal technology is challenging area for exploring new and innovative applications in the advanced cancer treatments. We have created a cancer optotheranostics using functional eutectic gallium-indium (EGaIn)-based LM nanoparticles that were successfully synthesized by various biomolecules (gelatin, DNA, lecithin, and bovine serum albumin), sonication, and quantum beam (γ-ray) radiation (Figure 1).

Free Research Field

生体医工学

Academic Significance and Societal Importance of the Research Achievements

これらの成果は、本研究の最終目標に掲げた腫瘍血管内部観察用のナノ粒子として充分に機能を発現できると期待している。また、今回開発した生体高分子のナノ粒子コーティング技術が、革新的がん診断・治療法の基礎に成り得ることを示すだけでなく、ナノテクノロジー、光学、量子ビーム工学といった幅広い研究領域における材料設計の技術基盤として貢献することを十分期待させるものである。