Research on anti-obese effcts of deoxygalactose

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H00947
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 40:Forestry and forest products science, applied aquatic science, and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Ushio Hideki 東京大学, 大学院農学生命科学研究科(農学部), 教授 (50251682)
• Co-Investigator(Kenkyū-buntansha): 細谷 孝充 東京医科歯科大学, 生体材料工学研究所, 教授 (60273124)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 肥満 / 褐藻 / ミトコンドリア / 脂質代謝 / β酸化 / マウス

Outline of Final Research Achievements

Fucoidan, a sulfated polysaccharide contained in brown algae, has been reported to exhibit various physiological activities such as anti-obesity and anti-tumor effects. DeOGal, a monosaccharide that constitutes fucoidan, inhibited the differentiation of preadipocytes into adipocytes in a dose-dependent manner, and decreased the expression of glycolytic rate-limiting enzymes Hk and Pfk and fatty acid synthase. Also, gene expressions that promote fatty acid oxidation and mitochondrial biogenesis were elevated. Phosphorylations of AMPK and its substrate ACC were enhanced, suggesting that DeOGal inhibits fat accumulation by activating the AMPK pathway, a master regulator of glucose and lipid metabolism, in adipocytes.

Free Research Field

水産化学

Academic Significance and Societal Importance of the Research Achievements

世界的な褐藻類の総生産は増加傾向にあるものの、その多くが加工残渣として廃棄されるため、新たな活用法が求められる。また、肥満は2型糖尿病や心血管疾患などの様々な代謝性疾患を引き起こすリスク要因とされ、深刻な公衆衛生問題である。さらに近年、世界的な肥満人口の増加が温室効果ガスの排出増加に関連する。褐藻由来DeOGalが肥満を効果的に抑制することは、褐藻類の新たな有効活用法に繋がるだけでなく、肥満人口低減にも繋がる。