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2023 Fiscal Year Final Research Report

Establishment of nonhuman primate models for human psychiatric disorders without gene modification and elucidation of its brain dysfunction

Research Project

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Project/Area Number 19H01039
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 51:Brain sciences and related fields
Research InstitutionKyoto University

Principal Investigator

NAKAMURA Katsuki  京都大学, ヒト行動進化研究センター, 教授 (70243110)

Co-Investigator(Kenkyū-buntansha) 伊藤 浩介  新潟大学, 脳研究所, 准教授 (30345516)
Project Period (FY) 2019-04-01 – 2024-03-31
Keywordsサイトカイン / マーモセット / マカクザル / 精神疾患 / 脳機能
Outline of Final Research Achievements

Using marmoset monkeys, we were able to induce abnormal behaviors similar to symptoms of psychiatric disorders such as abnormal social behavior, abnormal prefrontal cortex function, abnormal eye contact, abnormal circadian rhythm, hyperactivity, and abnormal auditory response by exposure to inflammatory cytokines during the perinatal period without gene editing methods. These results suggest that this model is useful as a primate model of psychiatric disorders. Further studies are expected to establish this model as the world's first useful primate model of psychiatric disorders.

Free Research Field

認知神経科学

Academic Significance and Societal Importance of the Research Achievements

統合失調症等の精神疾患は、その原因や治療法が不明である。遺伝子の連鎖解析によって同定されたどの遺伝子も統合失調症の原因遺伝子とはいえない。一方で、母体の炎症により発達障害や精神疾患の子どもが生まれる確率が高くなる。本研究では、ヒトを近縁とするマーモセットを対象として、炎症性サイトカイン暴露により、社会行動異常や前頭前野機能障害等の精神疾患症状を誘発することができた。炎症性サイトカインと精神疾患症状の関連を明らかにすることで精神疾患の理解や治療法の開発につながる。

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Published: 2025-01-30  

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