2023 Fiscal Year Final Research Report
Integrated modeling for pattern formation of cell polarity formation in asymmetric cell division
| Project/Area Number |
19H01805
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 12040:Applied mathematics and statistics-related
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| Research Institution | Kyoto University (2020-2023)
Hiroshima University (2019) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木村 暁 国立遺伝学研究所, 遺伝メカニズム研究系, 教授 (10365447)
栄 伸一郎 北海道大学, 理学研究院, 特任教授 (30201362)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | パターン形成 / 数理医学 / 初期発生 |
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| Outline of Final Research Achievements |
This research aims to construct an integrated mathematical model of polarity formation in asymmetric cell division of early embryogenesis, elucidate the mathematical structure of cell differentiation, and propose a universal regulatory mechanism for cellular diversification through biological experimentation. We constructed mathematical models based on the interaction of biomolecules within and outside the cell and they are applicable to a wide range of biological phenomena. Major achievements include elucidating the mathematical structure of polarity formation in cell membranes and cytoplasm through the mathematical model and demonstrating the mechanism of cell arrangement determination during the 4-cell stage. Additionally, the development of a Cell Morphology Model, which incorporates experimental data to create a three-dimensional model, was achieved. These methods are universal and applicable to other animal models.
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| Free Research Field |
数理生命医学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、非対称細胞分裂における極性形成機構を統合的に把握するための大域的モデリング手法を構築し、その数理的解析を通じて、従来の局所的モデリングでは説明できない現象を解明することを目指す。これにより、細胞分化および多様化に関する新たな理論と実証的知見が期待される。
また、研究の成果は、基礎生物学のみならず、再生医療およびがん研究にも大きな影響を与える可能性がある。幹細胞の分化メカニズムの解明は再生医療の発展に寄与し、がん細胞の異常分裂の理解は新規治療法の開発に繋がる。また、数理モデルを用いた生命現象の解析は教育分野でも重要な役割を果たし、次世代の科学者育成に貢献できる。
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