2022 Fiscal Year Final Research Report
Artificial molecular motors exploring "experimental physics of autonomous nanomachines"
| Project/Area Number |
19H01857
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 13040:Biophysics, chemical physics and soft matter physics-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 分子モーター / DNAナノテク |
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| Outline of Final Research Achievements |
The aim of this project was to create "experimental physics of autonomous nanomachines" by exploring the cooperative nature inside nanomachines through the realisation of high-performance artificial molecular motors that mimic biomolecular motors. In this study, we first realised conformational-changing leg structures by DNA oligami technology. Furthermore, a motor structure combining the legs was designed. Research will continue after the grant period, with the aim of experimentally realising this structure. For the ratchet-type motor, we propose a novel mechanism that combines unidirectionality and scalability due to structural asymmetry. Detailed numerical calculations suggest that explicit structural change is required to achieve the high operating performance of a biological motor.
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| Free Research Field |
生物物理学
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| Academic Significance and Societal Importance of the Research Achievements |
生体分子モーターは，超高性能の自律的ナノマシンである．これを模倣した人工モーターを実現できれば，生体分子モーターの理解が急速に進むだけでなく，効率的でしなやかな人工筋肉など，ナノマシンを基にした新しい工学技術の創出が期待できる．本課題では，人工モーターの新しい動作機構を提案し，詳細な数値計算により，構造変化を伴う動作が高性能なモーターには不可欠であることを見出した．さらに，DNAオリガミ技術で構造変化を伴う脚構造を実現し，構造変化により動作する人工モーター実現に向けた要素技術に成功した．このようなモデル系を詳細に調べることで「自律的ナノマシンの実験物理学」という新しい学理の構築が期待できる．
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