2022 Fiscal Year Final Research Report
Construction of link between musculoskeletal simulation and image-based mechanical analysis for development of treatment strategy of bone disease
| Project/Area Number |
19H02032
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 18010:Mechanics of materials and materials-related
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| Research Institution | Ryukoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
稲葉 裕 横浜市立大学, 医学研究科, 教授 (40336574)
小野 景子 同志社大学, 理工学部, 准教授 (80550235)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | バイオメカニクス / 筋骨格シミュレーション / 有限要素解析 / セグメンテーション / 変形性関節症 / 個体別モデリング / 歩行解析 / 歩容異常 |
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| Outline of Final Research Achievements |
In order to construct a link between musculoskeletal simulation and image-based mechanical analysis (FEA) of bone for development of treatment strategy of bone disease and establish new segmentation techniques for bone images, we developed a new segmentation technique using U-net and Textonboost, which was based on Boosting method, and verified its potency. We also performed subject-specific analysis of osteoarthritic gait, joint reaction forces, muscle forces and stress distribution in the bone around the hip using a workflow that derives forces from musculoskeletal simulation and imposes them on a FEA of bone. Then we found that joint reaction forces changed prominently with changes in individual muscle strength. In addition, we demonstrated that the developed new segmentation technique has the extraction accuracy as same as a traditional segmentation technique and needed less extraction time costs, suggesting potency of the new segmentation technique.
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| Free Research Field |
生体力学
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| Academic Significance and Societal Importance of the Research Achievements |
第一に，骨モデルに，患者固有の筋力，股関節反力を与える計算解析の枠組みを構築した．20年変化のない骨の荷重条件のモデル化方法に劇的な変化をもたらした．第二に，骨のイメージベース解析のネックを解消する新規の画像セグメンテーション法を開発した．骨モデルの高精度な構築を大幅な時間的短縮により実現し，今後の複数患者の解析，将来の巨大な患者データ解析への発想の転換を示唆した．第三に，変形性股関節症の経験的な診断・リハビリ方法に対し，力学的根拠のある治療戦略を示す足がかりを示し，高い社会貢献への可能性を示唆した．第四に，多様な計算と検証により，骨の力学的評価手法の高度化に貢献した．
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