2022 Fiscal Year Final Research Report
Spatial imaging system of gas emanated from human body for methods of disease screening
| Project/Area Number |
19H02150
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 21030:Measurement engineering-related
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| Research Institution | Tokyo University of Technology (2021-2022)
Tokyo Medical and Dental University (2019-2020) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
三林 浩二 東京医科歯科大学, 生体材料工学研究所, 教授 (40307236)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | バイオセンサ / イメージング / 酵素 / 生体ガス / 連続計測 |
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| Outline of Final Research Achievements |
We conducted research aiming to achieve high-sensitivity, selective, and spatial imaging of volatile chemical information contained in human volatiles emitted from exhaled breath and skin gas. Various volatile organic components (VOCs) released as exhaled breath and skin gases, associated with the human body's metabolism, exhibit significant spatial and temporal variations in concentration. Real-time imaging of these concentration changes and emission distributions has made it possible for the first time to visualize information of human volatiles. We successfully constructed a measurement system capable of information processing using a highly sensitive fluorescence imaging method for human volatiles, including ethanol gas and acetone gas, which are volatile chemical components associated with diseases and metabolic byproducts. We evaluated continuous measurements of exhaled breath and skin gas of human and discovered the potential for metabolic monitoring in this research project.
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| Free Research Field |
計測工学
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| Academic Significance and Societal Importance of the Research Achievements |
研究成果として、皮膚ガス中の疾患・代謝に伴うガス成分を高感度かつ選択的に、そして連続的に計測する技術を確立することができた。皮膚ガス成分の空間的・時間的情報を兼ね備えたイメージングを実現し、発生部位の特定や濃度の連続測定が可能な非侵襲な疾患スクリーニング法として応用の可能性が示された。生体ガス中のVOCsをリアルタイムに可視化するシステムを構築、空間中に存在するVOCs濃度分布情報・放出部位を計測すること実現したことは学術的にも価値のある研究である。簡便・非侵襲な代謝モニタリングへの可能性を示したことは社会的にも意義がある研究成果である。
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