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2021 Fiscal Year Final Research Report

Development of a novel liquid biopsy platform by combining microfluidics and integrated circuits

Research Project

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Project/Area Number 19H02569
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 28050:Nano/micro-systems-related
Research InstitutionThe University of Tokyo

Principal Investigator

KIM SooHyeon  東京大学, 生産技術研究所, 講師 (80709189)

Co-Investigator(Kenkyū-buntansha) 長阪 一憲  帝京大学, 医学部, 教授 (30624233)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywordsフローサイトメトリー / シリコン集積回路チップ / マイクロ流体デバイス / リキッドバイオプシー / 1細胞解析
Outline of Final Research Achievements

We developed a novel concept of parallelized flow cytometer which consists of an array of Single Photon Avalanche Diode (SPAD) aligned with parallelized microfluidic channels. The fluorescence signal from individual cells flowing each microfluidic channel were simultaneously detected with the SPADs by separating emission from excitation in time domain without a complex microscopy system. Moreover, by integrating microfluidics and CMOS technologies, a novel microfluidic system has been developed for trapping single cells and/or microparticles into designated locations, followed by parallelized analysis of trapped single cells. By integrating these technologies, we expect to establish a novel liquid biopsy platform capable of highly efficient separation and analysis of cancer cells from body fluids.

Free Research Field

ナノマイクロバイオシステム

Academic Significance and Societal Importance of the Research Achievements

細胞を高効率で同定できるフローサイトメトリー分野においては高速化に関する研究が行われているが、一本のキャピラリーを用いた既存の方法ではその物理的な限界があり、現状以上にスループットを向上するのは困難である。本研究は、発想を変えてフローサイトメーターを並列化することで、フローサイトメーターの機能・スループットの高度化を図るものであり、フローサイトメトリーの新たな展開を拓くことが期待できる。

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Published: 2023-01-30  

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