2022 Fiscal Year Final Research Report
Mechanisms and functions of non-equilibrium self-organising programmes supporting living systems.
| Project/Area Number |
19H02668
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 32010:Fundamental physical chemistry-related
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 自己組織化 / 非平衡 / 反応拡散 / アミロイドβ / リーゼガング |
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| Outline of Final Research Achievements |
Living systems are driven by a programme of progressive self-organisation along the potential gradient in nonequilibrium open systems, and this programme is an important principle governing the structure and function of life. In this study, the driving principle of the intermolecular interactions governed by this 'nonequilibrium self-organisation programme' is revealed through an explicit contrast with an equilibrium theoretical perspective, aiming to experimentally capture the factors that guarantee the robustness and flexibility of living systems. As a result, the influence of external chemical and physical factors on self-assembling structures in gel media has been clarified, as well as the peculiarities of non-equilibrium open systems for the formation mechanisms of biopolymer self-assembling structures used as pathological indicators.
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| Free Research Field |
物理化学
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| Academic Significance and Societal Importance of the Research Achievements |
本成果の意義の大部分は学術的な基礎研究に関するものである。これまで自己組織化は平衡系の定常状態としての構造解析や熱力学理解が主であり、形成過程における非平衡性は考慮されるものの、定常状態としての非平衡性の影響についての理解は遅れている。その様な中、本研究では複数の自己組織化現象に対する非平衡性の影響についての実験・理論的な研究を行い、物理化学的な学術的意義を与えたものである。一方、本成果の一部は地質学ならびに病理学にも関係するものでもあり、その波及効果として社会的意義をも有するものと考えられる。
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