Creation of artificial enzymes by combining metal-induced self-assembly and peptide chemistry

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H02697
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33010:Structural organic chemistry and physical organic chemistry-related
• Research Institution: Tokyo Institute of Technology (2021-2022); The University of Tokyo (2019-2020)
• Principal Investigator: Sawada Tomohisa 東京工業大学, 科学技術創成研究院, 准教授 (70625467)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 自己組織化 / ペプチド / 配位結合 / ナノ空間 / 分子認識 / 不斉反応 / トポロジー

Outline of Final Research Achievements

Metal-induced folding and assembly of short peptides can construct higher-order peptide nanostructures. In this study, exploration of new peptidic nanostructures based on sequence design was conducted, and also molecular recognition/reaction properties of their unique nanocavities were investigated.

Free Research Field

超分子化学

Academic Significance and Societal Importance of the Research Achievements

本研究において見出した、高次ペプチド構造の高効率合成法とナノ空間としての機能は、将来、生体系に匹敵するような人工酵素の実現に向けた重要な第一歩となりうる。