Nonlinear Development of Decarbonyl Transformations: Translocation, Deoxygenation and Metathesis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H02726
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 33020:Synthetic organic chemistry-related
• Research Institution: Waseda University
• Principal Investigator: Yamaguchi Junichiro 早稲田大学, 理工学術院, 教授 (00529026)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 芳香族エステル / 遷移金属触媒 / パラジウム / エステル / 結合活性化

Outline of Final Research Achievements

In this study, we have developed catalysts for the nonlinear development of decarbonylative coupling reactions of aromatic compounds that we found. Specifically, we initiated the development of highly challenging reactions, namely, ester dance reactions, deoxygenative transformation, and metathesis reactions, and realized them. In addition to the decarbonylative coupling reactions, three new methods were developed for the transformation of aromatic esters, which were mainly nucleophilic acyl reactions to carbonyl groups, and this research is considered to be significant from a synthetic chemistry perspective in that it has realized various effective uses of basic chemicals.

Free Research Field

有機合成化学

Academic Significance and Societal Importance of the Research Achievements

カルボニル基への求核的アシル化置換反応が主であった、芳香族エステルの変換を脱カルボニル型カップリング反応に加えて、さらに３つの新手法を開発し、基礎化学品の多様な有効利用を実現した点で本研究は合成化学的に大変有意義な研究であると考えられる。