Development of anti-cancer nanodrugs with high drug loading capacity and dispersion stability by surface modification

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H02785
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 35030:Organic functional materials-related
• Research Institution: Tohoku University
• Principal Investigator: Kasai Hitoshi 東北大学, 多元物質科学研究所, 教授 (30312680)
• Co-Investigator(Kenkyū-buntansha): 小関 良卓 東北大学, 多元物質科学研究所, 助教 (80780634)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: ドラッグデリバリーシステム / 再沈法 / 表面修飾 / 抗がん剤 / ナノ薬剤

Outline of Final Research Achievements

In the present study, surface modification with albumin was investigated to improve the drug delivery efficiency of nano-prodrugs consisted only of prodrug molecules. The results showed that the surface-modified nano-prodrugs exhibited better cellular uptake than the unmodified ones. In other words, the surface modification with albumin is expected to disperse well in the biological environment and exhibit high pharmacological activity by being taken up by cancer cells after transfer to tumor tissues.

Free Research Field

有機材料化学

Academic Significance and Societal Importance of the Research Achievements

本研究では、次世代ドラッグデリバリーシステムによる新規抗がん剤として期待されるナノ・プロドラッグの表面修飾技術を確立した。また、これまで不明であったナノ・プロドラッグの細胞内動態を解明し、今後のナノ・プロドラッグの抗がん剤としての実用化展開に向けて重要な知見が得られた。