Development of Synthetic Unimolecular Chaperon

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H02831
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 37010:Bio-related chemistry
• Research Institution: Tokyo Institute of Technology
• Principal Investigator: Kinbara Kazushi 東京工業大学, 生命理工学院, 教授 (30282578)
• Co-Investigator(Kenkyū-buntansha): 田中 良和 東北大学, 生命科学研究科, 教授 (20374225)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: イオン輸送 / 構造化PEG / 大環状化合物 / 有機金属触媒 / 分子シャペロン / タンパク質凝集抑制

Outline of Final Research Achievements

Based on the structured PEGs consisting of monodisperse short oligoethylene glycols, which suppress thermal protein aggregation, we planned to introduce ligand units for organometallic catalysts in the molecular skeleton. Indeed, we have succeeded in developing a systematic method for the systematic construction of structured PEG molecules, and also in synthesizing ligand molecules bearing imidazolinium moieties in the molecular skeleton. The ligand molecule was serendipitously found to act as an anion transporter across the lipid bilayer membranes, where interaction between the cationic C-H and anion was suggested to play an essential role for the transport capability . Also, we got results suggesting that the ligand molecules can be used for the synthesis of the desired organometallic catalysts.

Free Research Field

有機化学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は，触媒開発の意味ついて，物質合成ではない新たな機能に着目するという観点から，学術的，社会的に貢献できるものと期待される。また，偶然発見されたアニオン輸送体としてのはたらきについては，医学的観点からも意義のある結果である。