2022 Fiscal Year Final Research Report
Delivery of cargo in bacterial membrane vesicles
| Project/Area Number |
19H02866
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 38020:Applied microbiology-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | メンブレンベシクル / 微生物間相互作用 / 細菌間コミュニケーション / ファージ |
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| Outline of Final Research Achievements |
Most bacteria release extracellular membrane vesicles (membrane vesicles (MVs)) that have diverse functions. However, the details of the MV cargo uptake in bacteria have not been fully understood. In this project, we aimed to elucidate the mechanism of MV delivery. Given that the MV formation routes impact the MV cargos, we also analyzed the MV formation mechnisms along with the function of the MVs. As a result, we were able gain insights in to how MVs are formed and the cargos are delivery to the targetting cells.
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| Free Research Field |
微生物学
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| Academic Significance and Societal Importance of the Research Achievements |
MVはDNA、RNA、タンパク質、シグナル化合物などを運搬することで、遺伝子の水平伝播や細菌間コミュニケーション、抗生物質耐性等、多くの機能を併せ持ち、細菌の進化や生存戦略の根幹にも関わる。さらには、MVは生物材料としても非常に注目され、創薬などで新たな分野を切り拓いている。本課題の成果によって、MVに関する基礎的な知見が得られて、それをターゲットにした、微生物利用、制御分野に新たな切り口を提供することが期待される。
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