2021 Fiscal Year Final Research Report

The study on the role of choresterol biosynthesis pathway in the regulation od adipocyte function

Research Project

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Project/Area Number	19H02910
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 38050:Food sciences-related
Research Institution	Kyoto University
Principal Investigator	Goto Tsuyoshi 京都大学, 農学研究科, 准教授 (10550311)
Co-Investigator(Kenkyū-buntansha)	高橋春弥京都大学, 農学研究科, 助教 (30750369)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	脂肪組織 / コレステロール代謝 / 肥満
Outline of Final Research Achievements	In this study, we investigated the physiological roles of the cholesterol biosynthesis pathway in adipocytes. The findings in this study are summarized as below. We demonstrated that the cholesterol biosynthesis pathway in adipocytes plays an essential roles to maintain normal physiological functions of adipose tissues in adult mice using drug-inducible adipose tissue specific cholesterol biosynthesis pathway knockout mice which were established in this study. Moreover, it was suggested that requirement for cholesterol biosynthesis pathway in adipocytes are diferent between their depots. These findings are expected to be an important fundamental information for obesity and cardiovascular diseases which are closely related to dysfunction of adipocytes and cholesterol metabolism.
Free Research Field	食品科学
Academic Significance and Societal Importance of the Research Achievements	本研究により、脂肪細胞におけるコレステロール生合成経路の成獣における生理的意義が初めて明らかにされた。脂肪組織機能破綻は肥満に伴う代謝異常症の発症の主要因として考えられており、実際に過度の内臓脂肪蓄積状態はメタボリックシンドロームの必須の診断基準となっている。また「肥満」・「コレステロール代謝異常」はそれぞれ動脈硬化性疾患の危険因子となる。本研究により脂肪細胞におけるコレステロール合成経路の役割が明らかとなったことから、本研究成果は、肥満症や動脈硬化性疾患発症機構の新たな知見として、応用が期待される。