2021 Fiscal Year Final Research Report
Elucidation of intestinal tuft cell-expressed receptor function in type 2 innate immunity and its application to food science
| Project/Area Number |
19H02915
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 受容体 / 消化管 / 代謝 / 免疫 / 遺伝子破壊マウス / 刷子細胞 / 生体イメージング |
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| Outline of Final Research Achievements |
Using transgenic mice for in vivo live imaging in which intestinal tuft cells detecting helminths are fluorescent-labeled, we detected responses to succinic acid, salicin, and nematode excretory/secretory product in tuft cells or their surrounding cells. When succinic acid was administered, the number of type 2 innate lymphoid cells present in intestinal lamina propria was larger in tuft cell-localized Gprc5c knockout mice than in wild-type mice, suggesting that Gprc5c may suppress type 2 innate immune response during inflammation.
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| Free Research Field |
食品科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究より、刷子細胞頂端部に局在するオーファン受容体Gprc5cが、炎症時において2型自然免疫応答を抑制すると示唆されたことから、今後、Gprc5cのリガンドやその活性を調節する化合物を同定することによって、アレルギー性疾患や肥満・糖尿病の予防や治療に繋がることが期待される。
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