2022 Fiscal Year Final Research Report
Intracellular transport and metabolism of phospholipids involved in mitochondrial formation, and elucidation of pathological conditions caused by their damage
Project/Area Number |
19H03226
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 44010:Cell biology-related
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Research Institution | Kyushu University |
Principal Investigator |
Kuge Osamu 九州大学, 理学研究院, 教授 (30177977)
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Co-Investigator(Kenkyū-buntansha) |
宮田 暖 九州大学, 理学研究院, 助教 (10529093)
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Project Period (FY) |
2019-04-01 – 2023-03-31
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Keywords | リン脂質 / 細胞内輸送 / 代謝調節 / ミトコンドリア / 小胞体 |
Outline of Final Research Achievements |
Mitochondria are one of the intracellular structures whose functional impairment causes various diseases, and elucidation of their formation and maintenance is one of the most important research topics in modern cell biology. In this study, we attempted to elucidate the metabolism and function of phosphatidylethanolamine (PE), a phospholipid that is one of the constituents of mitochondria. As a result, we clarified the molecular mechanisms underlying control of localization and activity of phosphatidylserine decarboxylase, which synthesizes PE and is localized in both mitochondria and endoplasmic reticulum. In addition, we clarified that PE synthesis by this enzyme negatively regulates certain protein kinases, and that disruption of this regulation causes abnormalities in mitochondrial ATP synthesis and the cell cycle.
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Free Research Field |
脂質生物化学
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Academic Significance and Societal Importance of the Research Achievements |
ホスファチジルセリン脱炭酸酵素は、従来、ミトコンドリアにのみ存在するものと考えられていたが、最近その極一部が小胞体にも存在することが明らかにされた酵素である。従って、本研究によるこの少量の小胞体型酵素の重要性と局在制御機構の解明は、酵素の細胞内局在と分布の再検討の必要性という観点から、細胞生物学に大きな影響を与えるものである。また、ミトコンドリアPEが細胞周期制御において重要な役割を持つことが本研究により明らかにされたことから、癌など細胞周期が異常となった細胞におけるPE代謝の研究が、医療・医薬品開発に重要であることが再認識された。
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