2023 Fiscal Year Final Research Report
Variations in the systemic coordination of human cold adaptability and effects of exercise habits
| Project/Area Number |
19H03314
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 45060:Applied anthropology-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
後藤 一成 立命館大学, スポーツ健康科学部, 教授 (60508258)
二連木 晋輔 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70741156)
斉藤 昌之 北海道大学, 獣医学研究院, 名誉教授 (80036441)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 褐色脂肪組織 / 骨格筋 / 非震え代謝 / 震え代謝 / 寒冷適応能 |
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| Outline of Final Research Achievements |
This study aimed to comprehensively examine the physiological variation observed in human thermoregulatory function in cold environments from the perspective of systemic cooperation, and to examine the effects of cold exposure and exercise habits on the adaptation of thermoregulatory function. The thermoregulatory response was evaluated mainly through a mild cold exposure test in a climatic chamber. The results of this study showed that individuals with higher brown adipose tissue activity had higher non-shivering thermogenesis and also delayed the onset of shivering when the environmental temperature was lowered. These results suggested a mutually complementary functional coordination between non-shivering thermogenesis by brown fat and shivering thermogenesis by skeletal muscle, which is an interesting finding for explaining human body temperature regulation from the perspective of systemic coordination.
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| Free Research Field |
環境生理学
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| Academic Significance and Societal Importance of the Research Achievements |
近年、栄養学や健康科学の分野で行われる褐色脂肪研究が主に軽度寒冷曝露時の非震え代謝を評価しているのに対して、ヒトの体温調節機能を総合的に検討する上では、震え代謝の評価が欠かせなかった。また、ヒトの寒冷適応研究において、褐色脂肪による産熱亢進に関する知見は十分でなく、従来の震え産熱との関係性を示す必要があった。本研究において、特に褐色脂肪組織の活性に応じた非震え代謝応答と骨格筋を発現組織とする震え代謝応答の相互補完的機能協調作用が示されたことは、全身的協関の観点からヒトの体温調節機能の寒冷適応能を説明する上で興味深い知見となった。
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