2023 Fiscal Year Final Research Report
Association between genetic polymorphisms of melatonin receptor and psycho-physiological effects of simulated night shift work
| Project/Area Number |
19H03316
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 45060:Applied anthropology-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
太田 博樹 東京大学, 大学院理学系研究科(理学部), 教授 (40401228)
西村 貴孝 九州大学, 芸術工学研究院, 講師 (80713148)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 概日リズム / 交代制勤務 / メラトニン受容体遺伝子 / 一塩基多型 / 環境適応 / 光環境 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate the association between polymorphisms in the melatonin receptor genes (MTNR1A,MTNR1B) and physiological influence during night work. The results showed a significant difference in circadian rhythm phase delay induced by night shift in a single nucleotide polymorphism rs12506228 near MTNR1A, which has been reported to be associated with burnout in night-shift workers. Significant differences in glucose tolerance were also observed in rs1083096, MTNR1B, which has been reported to be associated with diabetes. These results provide a physiological background for the genetic factors involved in adaptation to night work.
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| Free Research Field |
生理人類学
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| Academic Significance and Societal Importance of the Research Achievements |
夜勤や交代制勤務は心身への負担が大きい。また、夜勤に対する耐性には個人差があることも知られている。本研究では疫学研究で燃え尽き症候群や糖尿病と関係があると報告されているメラトニン受容体の遺伝子多型に着目し、その生理的な背景を模擬的夜勤実験によって明らかにした点に学術的な意義ある。社会的な意義として、本研究の結果は夜勤・交替勤務の負担を軽減するうえで、個人差も踏まえた対策を検討する際の基礎データになると期待される。
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