Research on the mechanism regulating the time-course underlaying memory formation

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H03319
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 46010:Neuroscience-general-related
• Research Institution: Tohoku University
• Principal Investigator: Abe Kentaro 東北大学, 生命科学研究科, 教授 (70462653)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 転写因子 / 記憶形成 / 可塑性

Outline of Final Research Achievements

The crucial role of novel gene transcription within brain neurons during the memory formation is well established. Transcription factors, which are vital components that directly modulate gene expression, are known to orchestrate the plastic change of the nervous system via the dynamic influence to the transcriptome. Despite their importance, there are lack of understanding regarding the dynamic activity patterns of transcription factors within a live brain during the memory formation process. The current study had harnessed a cutting edge technology to elucidate the temporal dynamics of activity across a multitude of transcription factors in mice brain. Consequently, the study had revealed the pivotal role these transcription factors play in the regulation of time-course of memory formation.

Free Research Field

神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究では，記憶の形成過程において脳内に起こる遺伝子発現変化とその制御因子の活性変化を新規技術を用いて明らかにした。本研究によって確立した技術と知見は，記憶形成の分子機構を明らかにし，それにかかわる脳神経機構やそのような能力の発達機構を解明する研究の進捗に貢献する。