2023 Fiscal Year Final Research Report
Molecular basis underlying mechanoreception
| Project/Area Number |
19H03329
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | Aoyama Gakuin University |
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Principal Investigator |
Hirata Hiromi 青山学院大学, 理工学部, 教授 (60402450)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 神経 |
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| Outline of Final Research Achievements |
Sensory neurons are responsible for tactile perception. But other than the PIEZO1 receptor, the molecular mechanism of tactile perception in vivo remains largely unclear. In this study, we employed zebrafish sensory motor system into tactile research and utilized zebrafish mutants with abnormal tactile sensation. We identified a number of genes required for tactile perception and clarified their roles in tactile reception. For example, we found that PIGK, one of the subunits of GPI transamidase enzyme, which is required for the biosynthesis of GPI-anchored proteins, contributes to tactile perception by regulating the axonal localization of voltage-gated sodium channels in primary sensory neurons. We also found that a variant of the PIGK gene caused neurodevelopmental disorders in humans.
Translated with DeepL.com (free version)
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| Free Research Field |
脳科学
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| Academic Significance and Societal Importance of the Research Achievements |
触覚研究の分野ではPIEZO1という受容体分子は同定されて研究が進展したが、PIEZO1のサブユニットや制御因子など、触覚に関連する分子基盤の知見は今でも少なく、不明の点が多く残されている。皮膚感覚の異常は不快感をまねき、生活の質を著しく低下させることから、触覚の理解はヒトが健康的な生活をおくるのに重要な要素である。本研究で触覚に必要であるとわかった遺伝子のヒトでのバリアントが神経発達障害を引き起こすこともわかり、触覚の研究が触覚分野にとどまらず、広く神経疾患の理解に寄与することが示されたと言える。
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