2021 Fiscal Year Final Research Report
Regulation of humoral and cellular immune responses by innate immune receptor Gyc76C in Drosophila
| Project/Area Number |
19H03365
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 自然免疫 / ショウジョウバエ / 液性応答 / 細胞性応答 |
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| Outline of Final Research Achievements |
Innate immunity is involved in chronic inflammatory diseases, cancer metastasis, and lifestyle diseases by recognition of self-ligands. Therefore, understanding of regulation mechanisms of innate immune system is indispensable for understanding of these diseases and drug discovery. We have identified novel cGMP signaling pathway that modulates NF-κB pathway in innate immunity. In this study, we have identified a novel receptor, Gyc76C, which regulates innate immunity. In this study, we have elucidated one aspect of the molecular mechanism by which Gyc76C regulates humoral and cellular immunity.
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| Free Research Field |
生物系薬学
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| Academic Significance and Societal Importance of the Research Achievements |
自然免疫系が、当初その関連が予想もされなかった、慢性炎症疾患や、ガン転移、生活習慣病などと深い関わりがあることが明らかとなってきた。病原体成分では強い反応が一過的に誘導されるのに対して、慢性炎症では弱い反応が持続的に誘導される。したがって、それらの疾患の理解や創薬には、自然免疫がどのように調節されているかを理解することが重要である。本研究により、同じ受容体が、液性免疫と細胞性免疫を調節する分子機構が明らかとなり、自然免疫制御機構の理解に重要な進展が見られた。
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