Elucidation of molecular mechanism of novel lipid mediator, plasmalogen type lysophospholipid

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03372
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
• Research Institution: The University of Tokushima
• Principal Investigator: YAMAMOTO Kei 徳島大学, 大学院社会産業理工学研究部(生物資源産業学域), 准教授 (30304504)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: リゾリン脂質 / 乾癬

Outline of Final Research Achievements

In this study, we demonstrated that plasmalogene-type lysophospholipids (P-LPE) are localized in the epidermal layer and are a target for drug discovery based on the alleviation of psoriasis. We also organically synthesized A-LPE(trans), a non-enzymatic metabolite of P-LPE, and showed that this lysophospholipid has potential as a wound healing agent by promoting the differentiation and migration of epidermal cells.

Free Research Field

脂質生化学

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、表皮肥厚性疾患の発症要因に関する新しい概念の創成が期待され、皮膚炎症応答において新規脂質代謝系を明らかにした。また、基礎的な解析に加え、将来的に創薬開発も視野に入れており、本研究の成果を理論基盤とした創薬および予防治療の開発を展開したい。