2019 Fiscal Year Annual Research Report
Rescuing impaired learning in a mouse model for autism
| Project/Area Number |
19H03553
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
MIDDLETON STEVEN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (60526797)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | Hippocampus / Prefrontal cortex / SCN2A / Autism |
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| Outline of Annual Research Achievements |
The majority of the experimental equipment planned for this year has arrived, been set up and is currently being used to acquire data in line with the proposal. The majority of the data has been collected for the first goal of the grant. This includes recordings from prefrontal cortex and hippocampus, while mice perform a spatial working memory task. Analysis of this data has also begun and will continue extensively in the following year, to establish whether sharp-wave ripples differentially modulate network connectivity in response successful or failed trials. At this stage there has not been any unexpected problems regarding using either the equipment or the experimental protocols outlined in the proposal. Data analysis will continue in FY2020 together with the inclusion of SCN2A mice.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The current status of the research is approximately in line with the original plan outlined in the proposal. There was some money carried over, due to restrictions and delayed delivery dates owing to the ongoing pandemic. There were some minimal delays in acquiring equipment and experiment have to be scheduled appropriately to minimize social contact within the laboratory. However, the progress of the project is still almost exactly where it had been projected to be at this stage in the proposal.
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| Strategy for Future Research Activity |
The plan for the upcoming year will be to complete goal 2 of the original proposal which will involve further recording from control and SCN mice and extensive data analysis to establish how PFC and HPC activity gives rise to impaired learning in this mouse model of autism.
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