2021 Fiscal Year Annual Research Report

Rescuing impaired learning in a mouse model for autism

Research Project

Project/Area Number	19H03553
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	MIDDLETON STEVEN 国立研究開発法人理化学研究所, 脳神経科学研究センター, 研究員 (60526797)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	Hippocampus / Prefrontal cortex / SCN2A / Memory
Outline of Annual Research Achievements	The research has progressed as planned according to the research plan outlined for FY2021-2022. An extremely large amount of data has been recorded with the Neuropixel probes from mice performing memory dependent tasks, with both electrophysiology and behavioural analysis recorded simultaneously. Data analysis is currently being conducted, however given the large amount of data that is generated, and the multiple steps that are required for data analysis, this is the most time consuming step regarding the experiments. Spike sorting using kilosort, together with the preprocessing of data, such as concatenation and filtering are particularly slow. There was also a large investment of time in writing custom Matlab scripts to deal with synchronizing all the various data streams.
Research Progress Status	令和3年度が最終年度であるため、記入しない。
Strategy for Future Research Activity	令和3年度が最終年度であるため、記入しない。