2022 Fiscal Year Final Research Report
Strategic development research for control of distant metastatic cancer in local carbon ion radiotherapy
| Project/Area Number |
19H03597
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
吉田 由香里 群馬大学, 重粒子線医学推進機構, 助教 (90431717)
八高 知子 群馬大学, 重粒子線医学推進機構, 研究員 (50912317)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 炭素イオン線 / 遠隔転移 / 免疫応答 / ケモカイン / アラーミン |
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| Outline of Final Research Achievements |
We found that the combined use of hyperthermia (42oC, 30 minutes) and chemokine derivatives significantly inhibited cancer growth and suppress lung metastasis at the hyperthermia-treated site compared to placebo, chemokine alone, and hyperthermia alone.
In addition, we found that 1 Gy irradiation with carbon-ion beams and administration of chemically synthesized chemokine derivatives and alarmin molecules enhanced the antitumor effect compared with 1 Gy irradiation with carbon-ion beams alone. Furthermore, we confirmed that similar antitumor effects were observed by tail vein injection and local injection. On the other hand, we confirmed that tail intravenous injection was more effective in suppressing lung metastasis than local injection. However, we were not able to verify the effectiveness of various partial peptides as originally planned.
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| Free Research Field |
放射線生物学
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| Academic Significance and Societal Importance of the Research Achievements |
生体防御系に影響を与えない炭素イオン線によるがんの局所療法後に，ケモカイン誘導体によって種々の免疫細胞を活性化するという新しいコンセプトによるがん治療法として，動物実験レベルでその効果を確認した。この治療法は単独の細胞を活性化するのではなく，各種のリンパ球やNK細胞が協調して働くことに特徴がある。本研究は，生体内免疫系と，がんの関係解明のためにも，その成果の意義も大きい。
将来，動物実験での治験を基に，臨床研究に進むことにより人類の福祉に多大な貢献が期待できる。さらに，本研究を完遂し，革新的に炭素イオン線治療の治療成績向上に寄与する成果を出すことは，日本の責務だと考えている。
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