2022 Fiscal Year Final Research Report
Terminator B cells for IBD therapy
| Project/Area Number |
19H03645
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 53010:Gastroenterology-related
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2019-04-01 – 2023-03-31
|
| Keywords | 炎症性腸疾患 / ターミネーションB細胞 / Breg細胞 / Preg細胞 / NKB細胞 / インターロイキン10 / インターロイキン12 / 双方向性分化 |
|---|
| Outline of Final Research Achievements |
Immune responses are preserved by delicate balance of various cell types and cytokines to prevent the development of autoimmune diseases and allergy. Majority of previous studies for developing therapeutic approaches against these diseases have focused on targeting the pathogenic cell populations. In contrast, we herein focus on immune regulatory B cells and plasma blasts to preserve immune balance, which can prevent the development of pathogenic cells and also induce the termination of inflammatory responses in inflammatory bowel disease that is increasing continuously in Japan. We hope this project, if fully completed, would provide a novel insight into the development of an innovative therapeutic strategy that aims to complete cure rather than induction and maintenance of remission for inflammatory bowel disease.
|
| Free Research Field |
腸管免疫
|
| Academic Significance and Societal Importance of the Research Achievements |
免疫バランスの維持に寄与しながらも、研究の歴史が浅い「Preg」と「NKB」と呼ばれる細胞に着目し、マウスを用いた実験系で、これらの細胞が「どのようにして生まれ」そして「何によって抑制」されるかを解明した。これまで発見されている細胞群とは異なり、これらの細胞は環境因子に依存して多様性を持って生まれる事を見出しており学術的意義は高いと考えられる。
|
