The mechanism of impaired glucagon secretion in type 2 diabetes

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03707
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Gunma University
• Principal Investigator: KITAMURA TADAHIRO 群馬大学, 生体調節研究所, 教授 (20447262)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: グルカゴン

Outline of Final Research Achievements

In addition to abnormal insulin secretion, abnormal glucagon secretion is also a cause of type 2 diabetes, but the mechanism of abnormal secretion is still unknown. From the results of this study, it was clarified that the expression patterns of glucose transporters SGLT1 and GLUT1 are changed in pancreatic α cells of type 2 diabetes, resulting in abnormal glucagon secretion. In the future, it may lead to the development of new diabetes treatment drugs targeting SGLT1 or GLUT1 in αcells.

Free Research Field

代謝内分泌学

Academic Significance and Societal Importance of the Research Achievements

これまで、２型糖尿病の成因や病態解明についての研究はインスリン中心に行われてきた。本研究課題では、ほとんど注目されていなかったグルカゴンに注目して研究を行った点で学術的新規性や学術的意義が大きい。また、本研究の成果が新たな治療標的を明らかにしたことから、現在の糖尿病治療薬とは全く異なる作用機序を持つ新たな治療薬の開発につながる可能性もあり、社会的意義が大きい。