2022 Fiscal Year Final Research Report

Lymphatic imaging diagnosis based on lymphatic anatomy

Research Project

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Project/Area Number	19H03814
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 56070:Plastic and reconstructive surgery-related
Research Institution	Okayama University
Principal Investigator	Kimata Yoshihiro 岡山大学, 医歯薬学域, 教授 (50392345)
Co-Investigator(Kenkyū-buntansha)	品岡玲岡山大学, 医歯薬学域, 教授 (90724500) 小野敦川崎医療福祉大学, 医療技術学部, 教授 (20804743) 中嶋真大岡山大学, 大学病院, 主任診療放射線技師 (20886329) 山田潔岡山大学, 医歯薬学総合研究科, 准教授 (10319965)
Project Period (FY)	2019-04-01 – 2022-03-31
Keywords	リンパ管 / リンパ浮腫 / 解剖
Outline of Final Research Achievements	The anatomy of the lower extremity lymphatic vessel is clarified using ICG fluorescent lymphangiography and CT lymphangiography. It reveals that the lower extremity has at least four cutaneous territories, four groups of lymphatic vessels, each corresponding to three lymph nodes. Comparison of lymphoscintigraphy and ICG fluorescent lymphangiography in the same patients showed that the sensitivity of scintigraphy is markedly lower than that of ICG, especially in early-stage cases, where only about half of the cases can be detected. It has also been found that certain groups of lymphatic vessels are more likely to be affected in the early stages of the disease, and that as the disease progresses, defects in lymphatic vessel groups occur.
Free Research Field	形成外科
Academic Significance and Societal Importance of the Research Achievements	本研究により、下肢リンパ系の解剖が皮膚からリンパ節まで明らかになった。その情報はICGやシンチなどの画像検査の手技読影方法を改善させた。その改善された検査手技を持っても、特に早期の症例では、ICG蛍光リンパ管造影検査の方が感度の点で優れていることが明らかになっている。これらの情報は適切な画像診断法を提供し、早期発見に貢献する。