Studies on new diagnosis and treatments of metal allergy

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03835
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 57040:Regenerative dentistry and dental engineering-related
• Research Institution: Tohoku University
• Principal Investigator: Ogasawara Kouetsu 東北大学, 加齢医学研究所, 教授 (30323603)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: アレルギー

Outline of Final Research Achievements

We elucidated the molecular mechanism of the onset of palladium allergy. In vitro culture condition, we found that when antigen-presenting cells were added with a palladium solution, MHC class I expression was reduced and re-expressed on the antigen-presenting cells. It was also found that the antigenic peptide was changed in the process of expression reduction and recovery of MHC class I, and was replaced with a peptide that should not be normally expressed. Furthermore, it was clarified that allergic antigens are expressed and allergic T cells are activated by antigen-peptide substitution with palladium.

Free Research Field

基礎歯学

Academic Significance and Societal Importance of the Research Achievements

これまでパラジウムアレルギーの病因は不明だったため、パラジウムアレルギーの治療は、原因金属の置換や抗炎症薬投与などの対症療法にとどまっていた。本研究での成果をもとに、パラジウムによるMHCクラスIの一過性の細胞内在化を抑制すること、抗原ペプチドの置換を防ぐこと、などで、パラジウムアレルギーの新しい治療法が開発できると期待される。