A study on the effects of mineral oil on T cells

2024 Fiscal Year Final Research Report

• Project/Area Number: 19H03887
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: University of Miyazaki
• Principal Investigator: KURODA YOSHIKI 宮崎大学, 国際連携機構, 客員教授 (50234620)
• Co-Investigator(Kenkyū-buntansha): 日野浦 拓之 宮崎大学, 医学部, 講師 (90801168) ; 佐藤 実 産業医科大学, 産業保健学部, 訪問研究員 (90162487)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 自己抗体 / 鉱物油 / マウス

Outline of Final Research Achievements

Regarding the autoantibody induction ability of mineral oils, it was suggested that hexadecane, heptadecane, and octadecane with carbon numbers 16, 17, and 18 were the strongest, and it was also suggested that the induction may be related to the decreased expression of T cell surface receptors PD-1 and CTLA-4. It has been pointed out that antitumor agents using monoclonal antibodies against PD-1 and CTLA-4 show autoimmune disease-like symptoms as side effects, and this study was thought to show a similar phenomenon. However, the mechanism by which the expression of PD-1 and CTLA-4 is decreased by the administration of mineral oil is unknown, and further research is needed in the future.

Free Research Field

公衆衛生

Academic Significance and Societal Importance of the Research Achievements

鉱物油は日常生活で広く多用されている。この鉱物油の免疫影響を研究することで、世の中で汎用されている鉱物油の使用法について新たな示唆を与えるものである。また今回の研究でパタフィンおよびミネラルオイルの安全性も一部証明できたことは意義あることと思われる。ただしまだまだ鉱物油による自己抗体誘導にはわからない点が多いことからさらなる研究が必要であることも明白である。