Organophosphorus insecticide-induced lipid metabolism disruption in reproductive or neurodevelopmental toxicity

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03888
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58020:Hygiene and public health-related: including laboratory approach
• Research Institution: Nagoya City University
• Principal Investigator: Ito Yuki 名古屋市立大学, 医薬学総合研究院(医学), 准教授 (80452192)
• Co-Investigator(Kenkyū-buntansha): 冨澤 元博 東京農業大学, 生命科学部, 教授 (20621808)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 有機リン系殺虫剤

Outline of Final Research Achievements

Organophosphorus (OP) insecticides inhibit acetylcholine esterase (AchE) by phosphorylation and exert neurotoxic effects in insects. Recently, it has been reported that OP insecticides also affect the serine residue in other enzymes. The objective of this study is to clarify whether OP insecticides induce neurodevelopmental adverse effects in humans. In the prospective cohort study, we conducted questionnaire surveys on children’s neurodevelopment at 7.5 and 8 years of age and the responses were approximately 2600. In a crude analysis, no relationship between OP insecticide exposure levels in toddlers and neurodevelopmental outcomes at the same point was shown. We will reanalyze the association by adjusting for some potential confounders.

Free Research Field

衛生学

Academic Significance and Societal Importance of the Research Achievements

OP殺虫剤は作物保護や衛生害虫駆除に汎用されている。幼児におけるOP殺虫剤曝露は世界的に見ても殆ど報告がなく、幼児期のOP殺虫剤曝露と神経発達影響を明らかにすることができるのは現時点で我々のチームだけである。さらに、本研究では大規模コホート研究の一部の参加者を対象に実施しており、幼児期のOP殺虫剤曝露だけではなく、今後学童期のOP曝露との関係も明らかにすることができる。