2023 Fiscal Year Final Research Report

Research for the prediction of coronary artery complication associated with Kawasaki disease

Research Project

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Project/Area Number	19H03904
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research Institution	Wakayama Medical University
Principal Investigator	Kitano Naomi 和歌山県立医科大学, 医学部, 准教授 (40316097)
Co-Investigator(Kenkyū-buntansha)	鈴木崇之和歌山県立医科大学, 医学部, 助教 (40816691) 末永智浩和歌山県立医科大学, 医学部, 講師 (70433365) 垣本信幸和歌山県立医科大学, 医学部, 助教 (90614412) 土橋智弥和歌山県立医科大学, 医学部, 助教 (20828488) 山野貴司和歌山県立医科大学, 医学部, 講師 (40624151) 鈴木啓之和歌山県立医科大学, 医学部, 博士研究員 (80196865) 武内崇和歌山県立医科大学, 医学部, 大学院研究生 (10246522)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	川崎病 / 疫学 / 冠動脈瘤 / 血管炎 / 多施設共同研究 / 季節性 / 環境要因 / 宿主要因
Outline of Final Research Achievements	The etiology of Kawasaki disease (KD) is unknown, and the diagnosis is based on clinical symptoms and is considered a syndrome. The goal of acute treatment of KD is to prevent the development of coronary artery abnormalities (CAAs), and a treatment strategy that allows the optimal choice of treatment for each individual case is needed. We reported that the sex ratio differs according to the age group of patients with KD and that the distribution of the season in which KD occurred is characteristic. In this study, we identified an association between the proportion of patients with initial unresponsiveness to IVIG and increasing age. Differences in the risk factors were observed between initial unresponsiveness to IVIG and the deveropment of CAAs in infants with KD. Also, we examined that the age of the affected patients and the coronary artery measurements at the time of diagnosis were important factors in predicting the occurrence of CAAs before the start of acute treatment.
Free Research Field	疫学・公衆衛生学
Academic Significance and Societal Importance of the Research Achievements	本研究で川崎病罹患者の年齢層によって初期治療反応性と冠動脈異常発生との関係が異なることを明らかとした。このことは、急性期治療ガイドラインにおいて、冠動脈異常発生の事前予測（スコア等）の必要性と、罹患者の年齢層を加味した治療アルゴリズムの必要性を示唆するものである。