Maternal and child outcomes in hypertensive disorders of pregnancy considering bidirectional effect

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H03905
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Tohoku Medical and Pharmaceutical University
• Principal Investigator: Metoki Hirohito 東北医科薬科大学, 医学部, 教授 (20580377)
• Co-Investigator(Kenkyū-buntansha): 龍田 希 東北大学, 医学系研究科, 准教授 (40547709)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 母子保健 / 長期予後 / 高血圧 / 妊娠高血圧症候群 / 家庭血圧 / 出生コホート / 出生体重 / DOHaD

Outline of Final Research Achievements

Blood pressure variability and trajectories of blood pressure were found to be important for predicting future onset of hypertensive disorders of pregnancy and infant birth weight. Fasting blood glucose and high HbA1c levels at <24 weeks' gestation were risk factors for hypertensive disorders of pregnancy, and HbA1c was more strongly associated with hypertensive disorders of pregnancy than fasting blood glucose. In addition, a history of hypertensive disorders of pregnancy was associated with an increased risk of future diabetes and hypertension. The infant was delivered at low birth weight was also associated with subsequent prevalence of hypertension in the mother.

Free Research Field

臨床疫学

Academic Significance and Societal Importance of the Research Achievements

BOSHI研究の研究成果は、白衣効果の大きさについて2021年に報告されたメタ解析でも同様の結果が確認された。喫煙と妊娠高血圧症候群に関するメタ解析でも他のコホートとほぼ同様の結果を示した。妊娠期間中の血圧と児の体重との関連は妊娠高血圧症候群の診療指針2021でも引用されている。血圧変化の軌跡が児の体重に及ぼす影響については国際的にも同様に報告がなされるようになり、今後、発症予測の面からも重要である。