2023 Fiscal Year Final Research Report
Role of internal feedback neural pathway in functional recovery from spinal cord injuries
| Project/Area Number |
19H03975
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59010:Rehabilitation science-related
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| Research Institution | Tamagawa University (2021-2023)
Kyoto University (2019-2020) |
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Principal Investigator |
TAKEI Tomohiko 玉川大学, 脳科学研究所, 准教授 (50527950)
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| Co-Investigator(Kenkyū-buntansha) |
伊佐 正 京都大学, 医学研究科, 教授 (20212805)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | 運動制御 / 遠心性コピー / 化学遺伝学 / 皮質電位記録 |
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| Outline of Final Research Achievements |
To determine the contribution of the ‘efference copy’ of motor commands to motor control in normal conditions and during motor disorders, we aimed to establish techniques for recording and manipulating the ' efference copy' pathways in non-human primates. First, we attempted to inhibit the neural pathway transmitting 'efference copy' from the corticospinal tract to the lateral reticular nucleus with the chemogenetic tools but failed to show significant behavioural and electrophysiological changes. Therefore, we further recorded the neural activity in the motor-related areas that are the source of motor commands and conducted a detailed behavioural analysis using torque perturbation, which showed neural activity related to preparation for motor responses. These findings have promoted further research to clarify the cortico-cerebellar interaction and their function with regard to 'efference copy' for the preparation of motor responses.
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| Free Research Field |
神経生理学
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| Academic Significance and Societal Importance of the Research Achievements |
従来の脊髄損傷に関する研究では、いかに元々の神経連絡や運動機能を「復元」するかということに主眼が置かれてきた。しかし、現段階の技術では完全な神経再生は難しく、また他の神経経路による機能代償も限定的である。そのため、このような不完全な神経回路のもとでは患者自身が「思い通りに動かない身体」を受容してそれに対して自分の行動を適応させること、すなわち運動機能の「復元」ではなく「再獲得」を目指していくことが重要である。本研究成果は、自分の身体状態の把握と考えられる「遠心性コピー」の神経メカニズムの理解を前進させた。この知見を元にさらなる研究により運動障害の神経機構が明らかになると期待される。
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