Rapid active muscle hyperemia at the onset of exercise and elucidation of training effects: using diffuse correlation spectroscopy

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H04006
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Meiji University
• Principal Investigator: Ichinose Masashi 明治大学, 経営学部, 専任教授 (10551476)
• Co-Investigator(Kenkyū-buntansha): 小野 弓絵 明治大学, 理工学部, 専任教授 (10360207)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: スポーツ生理学 / 生体医工学 / 循環調節 / 末梢血流量 / 光技術

Outline of Final Research Achievements

In this study, we developed a new blood flow measurement technique using diffusion correlation spectroscopy (DCS) to measure temporal changes in blood flow in the active muscle microcirculation immediately after the start of exercise, which cannot be detected by conventional active limb blood flow measurement methods and evaluated its usefulness and investigated the mechanism of rapid blood flow response. Using the developed DCS-based blood flow measurement technique, the rapid rise in blood flow elicited by a single muscle contraction was successfully evaluated quantitatively. Furthermore, we showed that skeletal muscle pump and metabolic factors play important roles in the rapid blood flow response. We also demonstrated that increased hydrostatic pressure in skeletal muscle microvessels enhances and accelerates the muscle contraction-dependent and -independent increase in blood flow.

Free Research Field

スポーツ生理学

Academic Significance and Societal Importance of the Research Achievements

本研究において開発・確立した拡散相関分光法を用いた単回筋収縮に対する血流反応計測法により，これまで検討することが困難であった活動筋微小血管における運動開始時の迅速な血流・血管応答を定量評価し，そのメカニズムを調べることが可能となった。本研究の成果は，活動筋微小循環における血流調節メカニズムの解明に貢献するとともに，運動による健康増進や安全で効果的なトレーニング法などを考えるうえでも有意義な知見となる。