Effect of exercise and nutritional intervention on genetic risk score in sarcopenic obesity patients

2022 Fiscal Year Final Research Report

• Project/Area Number: 19H04039
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Ritsumeikan University
• Principal Investigator: Sanada Kiyoshi 立命館大学, スポーツ健康科学部, 教授 (50421227)
• Co-Investigator(Kenkyū-buntansha): 家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: サルコペニア / 肥満 / 遺伝子多型 / 運動処方 / 栄養処方

Outline of Final Research Achievements

In this study, we conducted a literature review on the prevention of sarcopenia and its genetic effects due to exercise, a cross-sectional study on the relationship between depression and physical activity in obese subjects with sarcopenia, and a study on sarcopenia and atherosclerosis-related indices in middle-aged and elderly women. Interaction with iron intake, exercise intervention for sarcopenic obesity was conducted. To summarize the relationships between sarcopenia-related genes and muscle mass and muscle function, they can be classified into (1) genes related to physical strength, (2) genes related to skeletal muscle metabolism, and (3) genes related to inflammation. Sarcopenic obesity showed depressive symptoms when the amount of daily activity was low. In addition, continuous aqua exercise can be expected to reduce body fat.

Free Research Field

応用健康科学

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、サルコペニア肥満者の運動療法に活用することができる。特にACEやACTN3遺伝子多型の保有者は体力の向上を、VDRやIGF-1遺伝子多型の保有者は、筋量の維持・増加と運動機能の向上を、CRP遺伝子多型の保有者は、炎症反応抑制のための腹部肥満の予防などが求められると考えられる。また、高齢女性においては、家事などの生活活動が抑うつ予防に重要である可能性やアクアエクササイズによるサルコペニア肥満者の減量効果が確認できた。