2023 Fiscal Year Final Research Report

A Study on the Health Effects of Heated Tobacco Products Measured by Changes in Pulmonary Microcirculation and Alveolar Macrophage Behavior

Research Project

PDF

Project/Area Number	19H04041
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 59040:Nutrition science and health science-related
Research Institution	National Institute of Public Health
Principal Investigator	Ushiyama Akira 国立保健医療科学院, その他部局等, 部長 (60291118)
Co-Investigator(Kenkyū-buntansha)	小笠原裕樹明治薬科大学, 薬学部, 教授 (20231219) 中舘和彦明治薬科大学, 薬学部, 教授 (80372895) 稲葉洋平国立保健医療科学院, その他部局等, 上席主任研究官 (80446583) 服部研之明治薬科大学, 薬学部, 教授 (90306663)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	加熱式たばこ / 生体影響 / 動物実験
Outline of Final Research Achievements	In this study, we developed a highly accurate exposure device based on the characteristics of heated tobacco products and demonstrated its potential for use in evaluating biological effects. Exposure of mice to IQOS mainstream smoke was shown to cause an oxidative stress response accompanied by a decrease in the concentration of reduced glutathione in alveolar macrophages, as well as alveolar macrophage foaming. We also showed that even short-term exposure can cause changes in cytokine levels and alveolar morphology. We demonstrated the usefulness of a new technique that can evaluate the immediate effects of smoking through imaging techniques that measure blood flow dynamics in the pulmonary microvasculature during exposure to mainstream aerosol. This study has provided evidence for the identification of the health hazards of heated tobacco.
Free Research Field	衛生学
Academic Significance and Societal Importance of the Research Achievements	加熱式たばこについて、人の疫学的な調査で健康影響を明らかになるまでに、更に時間が必要である。しかし、健康影響があるとすればエビデンスを蓄積していく必要がある。本研究では、加熱式たばこの特性に基づく高精度のばく露装置を開発し、新たな健康脅威となるかもしれない加熱式たばこの動物実験の実施可能性において新たな領域を開拓した。マウスを用いて実際にばく露実験を行い、生体影響の一部を明らかにしたことは、今度の加熱式たばこの健康ハザード評価において重要な知見となるエビデンスを提供できた。公衆衛生学、衛生学の観点から、非常に意義のある研究結果を示すことができた。