Assessing causal relationship of skeletal muscle- and fitness-related myokines with cardiometabolic risk factors

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H04065
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Waseda University
• Principal Investigator: Tanisawa Kumpei 早稲田大学, スポーツ科学学術院, 専任講師 (50771812)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: マイオカイン / 心血管代謝リスク / 骨格筋量 / 体力 / ゲノムワイド関連解析 / メンデルランダム化解析

Outline of Final Research Achievements

In the present study, we assessed causal relationships between serum levels of skeletal-muscle- and fitness-related myokines and cardiometabolic risk factors using a Mendelian randomization analysis in 939 middle-aged and elderly men and women. We revealed that fasting serum levels of myokines X, Y, Z that were analyzed in the present study, were negatively correlated with skeletal mass index, and that higher serum levels of these myokines were associated with higher cardiometabolic risks. Furthermore, we explored single nucleotide polymorphisms (SNPs) associated with these myokine levels using a genome-wide association study and performed Mendelian randomization analyses using the SNPs that were associated with serum myokine levels. The Mendelian randomization analyses suggested the causal relationships of myokines X and Z with several cardiometabolic risk factors.

Free Research Field

運動生理・生化学、スポーツ遺伝学

Academic Significance and Societal Importance of the Research Achievements

運動の多岐に渡る恩恵を媒介する因子として、骨格筋から分泌されるマイオカインが注目を集めている。しかし、マイオカインの効果を報告した研究のほとんどは細胞・動物レベルの研究であり、ヒトにおけるエビデンスが不足している。したがって、ヒトを対象とした研究により血清マイオカイン濃度と心血管代謝リスク因子の関連についてエビデンスを提供することは、学術的・社会的に意義があると考えられる。