2021 Fiscal Year Final Research Report
Development and practice of "adaptive risk assessment based on biological monitoring" of insecticide
| Project/Area Number |
19H04277
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 63030:Chemical substance influence on environment-related
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
横山 俊史 神戸大学, 農学研究科, 助教 (10380156)
池中 良徳 北海道大学, 獣医学研究院, 教授 (40543509)
平野 哲史 富山大学, 学術研究部薬学・和漢系, 助教 (70804590)
市川 剛 獨協医科大学, 医学部, 非常勤講師 (80438712)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 殺虫剤（農薬） / 生物学的モニタリング / 適応的リスク評価法 / ネオニコチノイド / AOP（有害発現経路） / 発達神経毒性 / 性差 / 無毒性量（NOAEL） |
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| Outline of Final Research Achievements |
Since developmental neurotoxicity is not included in the mandatory safety assessment of pesticides, it has been questioned whether the nontoxic amount (NOAEL) specified in the current law and the acceptable daily intake calculated from the NOAEL are really the values to ensure our health. In this study, we conducted a trans-omics analysis of exposure of mammalian animals to systemic pesticides (neonicotinoids and fipronil), which are currently the mainstay of pesticides, below the NOAEL. The results showed that the pesticides had effects on higher brain functions, such as cognitive-emotional changes including hyperactivity and anxiety-like behavior, and that the effects were greater in immunotoxicity, sex differences, and old age. We also found developmental neurotoxicity and transgenerational effects, and reported the weakness of the safety and risk assessment of current pesticides ahead of the rest of the world.
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| Free Research Field |
環境分子遺伝学，動物分子形態学
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| Academic Significance and Societal Importance of the Research Achievements |
現在，主に使われている浸透性農薬による高次脳機能の攪乱作用の全貌を明らかにすることができた点は大きな学術的意義がある．とくに2021年から施行されている「農薬再評価」に向けて，本研究成果により，浸透性農薬が中枢神経系に及ぼす影響に関する新規エビデンスとして学術論文や学会での発表を通じて提供することができた．一方，農薬等の環境中微量化学物質曝露に伴う子供達へのリスクを低減するためにも，現行の農薬の安全性とリスク評価の脆弱性を明らかにした点は極めて大きな社会的意義を有し，新たな視点から毒性評価を行う必要性を示すことができた．
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