2021 Fiscal Year Final Research Report
Ecotoxicological assessment of a naturally occurring dioxin, 1,3,7-Tribromodibenzo-p-dioxin in marine invertebrates
| Project/Area Number |
19H04286
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 63040:Environmental impact assessment-related
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| Research Institution | Tokai University (2020-2021)
National Institute of Technology, Kumamoto College (2019) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
石橋 弘志 愛媛大学, 農学研究科, 准教授 (90403857)
内田 雅也 有明工業高等専門学校, 創造工学科, 准教授 (80575267)
小林 淳 熊本県立大学, 環境共生学部, 教授 (00414368)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 臭素化ダイオキシン / 甲殻類 / 二枚貝 / トランスクリプトーム / 環境化学物質 / 生態毒性 / 化学分析 |
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| Outline of Final Research Achievements |
Natural polybrominated dibenzo-p-dioxin (PBDD) congeners including di-/triBDDs are detected in marine invertebrates. To evaluate the ecotoxicological impact of triBDDs on marine invertebrates, we investigated the effect of 1,3,7-TriBDD on growth of mysids. Exposure to 20 μg/L 1,3,7-TriBDD resulted in a significant decrease in growth. Transcriptomic analysis of the digestive gland of mussels indicated that naturally occurring PBDDs may have a potential to elicit adverse effects on neurogeneration through a unique mechanism in the mussels. Moreover, we analyzed tri-/tetraBDDs in marine organisms including fishes, shrimps and bivalves collected from the Ariake Sea. The high level of triBDDs was found in oyster and mussel samples, and 1,3,7/1,3,8-TriBDDs were the predominant congeners. These results suggest the bioaccumulation of triBDD and their potential ecotoxicological effect.
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| Free Research Field |
環境毒性学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の成果から、海産甲殻類や二枚貝に対する臭素化ダイオキシン類の潜在的毒性リスクを評価することができた。また、実験材料として情報基盤に乏しい海産無脊椎動物の分子基盤、ゲノム情報の整備に進展がみられたため新規性の高い知見が得られた。特に1,3,7-TriBDDの毒性影響濃度を特定できたことから、国際機関の環境政策への適用を目指し、沿岸環境における塩素系/臭素系ダイオキシンの包括的な毒性リスクの把握に貢献できる点で社会的意義は非常に大きい。
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