Development of drug delivery system to the brain

2021 Fiscal Year Final Research Report

• Project/Area Number: 19H04468
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 90120:Biomaterials-related
• Research Institution: Osaka University
• Principal Investigator: Kondoh Masuo 大阪大学, 薬学研究科, 教授 (50309697)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 脳内薬物送達

Outline of Final Research Achievements

The population is aging in the world, and the elderly population is expected to exceed 1.4 billion by 2050. Patients with central nervous system (CNS) diseases is expected to increase exponentially in the aging society. Although pharmaceutical companies have been making strenuous efforts to develop CNS drugs, the success rate of CNS drug is still the lowest among diseases. One of the reasons is that blood-brain barrier (BBB) prevents drug delivery to the brain. In this study, we attempted to develop a method to deliver drugs to the brain across the BBB, and we proved a novel concept for drug delivery to the brain. We will investigate safety and efficacy of the developed method.

Free Research Field

規制科学、薬物送達学

Academic Significance and Societal Importance of the Research Achievements

今回開発した方法は、将来的に色々な薬を脳内に運ぶために利用できます。例えば、低分子、抗体などの高分子に加え、粒子も脳内に運ぶことができるかもしれません。粒子を運ぶことができれば、粒子中の薬をかえることでCNS疾患治療に大きく貢献できると期待されます。65歳を過ぎるとCNS疾患の発症率が急激に増加することから、健康寿命を延ばすにはCNS薬の開発が重要です。この研究成果をさらに磨くことで健康社会に実現に貢献したいと思っています。