2023 Fiscal Year Final Research Report
Effects of pore size on carbonate apatite bone substitute's osteoconductivity and replacement to bone
| Project/Area Number |
19H04469
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 90120:Biomaterials-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 炭酸アパタイト / 人工骨 / 骨補填材 / 連通多孔体 |
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| Outline of Final Research Achievements |
Fully interconnected porous carbonate apatite block was found to be fabricated by fabricating fully interconnected porous precursor or calcium carbonate block.
This is due to the three-dimensional compositional transformation through dissolution-precipitation reaction. Regardless of the interconnected porous structure, one, two or three-dimensional porous structure, new bone was formed at the center of the block after implantation for 4 weeks. On the other hand, bone formation nature was different when pore morphology was different even when key interconnected structure was the same.
It was demonstrated that optimization of the pore structure is important for improving the capability of carbonate apatite block.
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| Free Research Field |
生体材料学
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢社会を迎え、骨再建術が急増している。自家骨移植（患者自身の骨を採取して骨欠損治療を行う手法）には健全部位への侵襲という重篤な問題があり、自家骨に匹敵する機能を備える人工骨が望まれている。
本研究で開発した連通多孔性炭酸アパタイト人工骨は連通構造に関わらずいずれも埋植４週目で中央部まで骨形成され、さらに骨リモデリングによって新しい骨に置換される理想的な人工骨となる可能性が高い。
また、マクロ的な連通構造だけでなく、ミクロレベルの気孔形態が骨形成に影響を及ぼすことがわかった。本研究結果を基盤に最適化した連通多孔性炭酸アパタイトブロック状骨補填材の最適化が望まれる。
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