2022 Fiscal Year Annual Research Report
Elucidating the Dynamics of Memory
| Project/Area Number |
19H05646
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
McHugh Thomas 国立研究開発法人理化学研究所, 脳神経科学研究センター, チームリーダー (50553731)
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| Project Period (FY) |
2019-06-26 – 2024-03-31
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| Keywords | hippocampus / cortex / oscillations / memory |
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| Outline of Annual Research Achievements |
During the previous fiscal year we have continued to conducted experiments investigating how oscillations and spiking organize the precise activity of subsets of neurons related to memory and experience. We published a manuscript detailing a state-dependent impact of transient silencing of the CA2 subfield of the hippocampus on the dynamics of network activity in the structure, featuring our newly developed machine learning based algorithm for the decoding of position based on the spikes recorded on a single tetrode. This allowed us, for the first time, to look at positional decoding in a subfield and state dependent manner. We have also published a review paper on our previous work on the differential contributions of the CA2 and CA3 subfields to sharp-wave ripples and replay. We have collected data using closed-loop optogenetics and using high-density neuropixels recording that will be analyzed in the coming fiscal year.
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| Research Progress Status |
翌年度、交付申請を辞退するため、記入しない。
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| Strategy for Future Research Activity |
翌年度、交付申請を辞退するため、記入しない。
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